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News Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia
An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose during 2 years of treatment while maintaining and deepening the alleviation of schizophrenia symptoms.
News Diabetic Nephropathy and COVID-19: Fatal Connection?
People with diabetes and diabetic kidney disease exhibit higher mortality and risk of severe illness in connection with COVID-19. The worse prognosis of these patients likely has multiple reasons; in the following overview, we will focus mainly on the cellular receptor of the SARS-CoV-2 virus – angiotensin-converting enzyme 2 (ACE2).
News Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics
Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the clinical symptoms of asthma differ between patients with and without this mutation.
News Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19
Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent acute lung injury. Recently, it has been found that AAT also mitigates the course of COVID-19 disease by hindering the entry of the SARS-CoV-2 coronavirus into host cells. This dual antiviral and anti-inflammatory action makes AAT an excellent candidate for COVID-19 treatment.
News To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?
A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline phosphatase (ALP), alanine aminotransferase (ALT), or bilirubin can reach several percent in both positive and negative directions.
News Options for Preventing Enteral Nutrition Intolerance in Mechanically Ventilated Patients in the ICU
Standards of care for critically ill patients recommend enteral nutrition for those on mechanical ventilation. A recently published study addressed the question of how to identify patients at risk of enteral nutrition intolerance (ENI) and how to subsequently prevent this intolerance, which may be associated with worse clinical outcomes.
News European Registry of Patients with Alpha-1 Antitrypsin Deficiency EARCO Enrolls Patients
Insufficient identification of patients with alpha-1 antitrypsin deficiency (AATD) and a lack of knowledge about this disease have led to the launch of the European Registry EARCO, which is currently enrolling patients. The aim is to better describe the pathophysiology of the disease and the prognosis of these patients, and to create a validated prognostic tool to aid clinical decision-making.
News Can alpha-1-antitrypsin deficiency affect severity and higher mortality in COVID-19 patients?
Alpha-1-antitrypsin (AAT) deficiency is commonly found in the European population. The most cases are recorded in countries with the highest COVID-19 mortality rates. Are there direct correlations?
News Effectiveness of the Venetoclax/Rituximab Combination in the Treatment of CLL – 5-Year Follow-Up Data
At the virtual 62nd Annual Meeting of the American Society of Hematology (ASH), updated results of a clinical evaluation of the treatment of patients with refractory/relapsed chronic lymphocytic leukemia (R/R CLL) using venetoclax in combination with rituximab were presented.
News Does Beta-Blocker Therapy Reduce the Cardiovascular Benefit of Aerobic Exercise in Patients with Arterial Hypertension?
Regular aerobic exercise is generally recommended for patients suffering from arterial hypertension to reduce blood pressure values, improve physical fitness, and other parameters. The intensity of exercise is most often derived from the target heart rate, which is pharmacologically influenced in patients on beta-blockers. The question, therefore, is whether aerobic exercise brings the same cardiovascular benefit to this group of patients as it does to those not taking beta-blockers.
News Experiences with Long-term Treatment of Psoriasis with Interleukin 17A Inhibitor
The current publication of the long-term extension of the UNCOVER-3 study, which focused on the treatment of psoriasis with ixekizumab, describes the efficacy and safety of 4 years of use of this drug.
News Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice
An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and efficacy of obeticholic acid treatment in patients with primary biliary cholangitis (PBC) under real-life conditions after 12 months correspond to the results of clinical trials.
News Prescription Restrictions on Antidiabetics Authorized for Prescription by General Practitioners - Status as of October 2020
Diabetes mellitus (DM) has become an increasing problem worldwide in recent years. Long-term complications of DM lead to increased morbidity and mortality in the diabetic population, and their prevention determines the main treatment goals of DM. The treatment and management of patients with type 2 diabetes (DM2) are provided by either a general practitioner's office (GP) or a diabetology clinic. According to available data, over 200,000 patients with DM2 are currently treated and managed in GP offices.
News Dysregulation of microRNA Expression After Treatment with Anti-EGFR Antibodies
A team of researchers from Plzeň decided to verify whether treatment with anti-EGFR antibodies changes the expression of selected microRNAs in patients with metastatic colorectal carcinoma (mCRC). They have just published their findings in the autumn issue of the journal Cancer Genomics Proteomics.
News Panitumumab in 1st Line in Older Patients – Results of the PANDA Study
The phase II PANDA study evaluated the regimens FOLFOX + panitumumab versus 5-FU + panitumumab in the 1st line treatment of patients with wt-RAS/BRAF metastatic colorectal cancer (mCRC).