Molecular- genetic analysis of tumor- suppressor genes PTEN and TP53 in a patient with endometrial carcinoma.
Authors:
E. Radzo 1; V. Šišovský 2; P. Sýkora 1; V. Repiská 1
Authors‘ workplace:
Univerzita Komenského v Bratislave, Lekárska fakulta, Ústav lekárskej biológie a genetiky
1; Univerzita Komenského v Bratislave, Lekárska fakulta, Ústav patologickej anatómie
2
Published in:
Prakt Gyn 2009; 13(4): 225-227
Overview
Molecular- genetic analysis of tumor- suppressor genes PTEN and TP53 in a patient with endometrial carcinoma. Endometrial carcinoma is the most common malignant tumor of female genitals in the developed countries. Recently, certain genes have been found to contribute to the development of endometrial carcinoma, including TP53, KRAS, b- catenin and PTEN. PTEN is as tumor- suppressor gene, mutation of which has been described in several studies of various types of tumors. PTEN was identified in 1997 on chromosome 10 (10q23.3) and encodes tyrosine phosphatase. Tumor- suppressor gene TP53 (17p13.1, coding region 2629 bp) encodes a protein consisting of 393 amino acids, and its tetramer form acts as a functional protein. We identified PTEN gene mutation and TP53 gene polymorphism in the examined endometrial tissue.
Key words:
endometrial carcinoma – tumor- suppressor gene – gene mutation – gene polymorphism
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Practical Gynecology
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