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proLékaře.cz / Journals / Perspectives in Surgery / 2023 - 9

Surgical therapy of chronic lung allograft dysfunction

Czech version

Authors: R. Novysedlák 1*;  J. Tavandžis 1*;  J. Balko 2;  Z. Ozaniak Střížová 3;  J. Vachtenheim Jr 1;  R. Lischke 1
Authors‘ workplace: Tito autoři se na této práci podíleli stejným dílem *;  Národní program transplantace plic pro Českou a Slovenskou republiku, III. chirurgická klinika 1. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha, Česká republika 1;  Ústav patologie a molekulární medicíny 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha, Česká republika 2;  Ústav imunologie 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha, Česká republika 3
Published in: Rozhl. Chir., 2023, roč. 102, č. 9, s. 345-351.
Category: Review
doi: https://doi.org/10.33699/PIS.2023.102.9.345–351

Overview

Lung transplantation has become a standardized and widely accepted treatment modality for selected end-stage lung diseases. Many factors influ- ence the long-term survival of patients after lung transplantation. One of the most important is clearly the development of chronic lung allograft dysfunction (CLAD). This review summarizes current knowledge of the histopathology of CLAD and its clinical characteristics. It also describes lung re-transplantation as the only causal therapy, its possible complications, and outcomes in standard and high-urgency patients awaiting a suitable organ with extracorporeal membrane oxygenation support. Fundoplication is an important surgical modality potentially leading to an improvement of the patients’ condition. The indications and outcomes of this surgical procedure are discussed in a separate chapter. In addition, several nonsurgical treatment options aimed at slowing the progression of CLAD are outlined, as well as ongoing research focused on extending the life of these patients.

Keywords:

Lung transplantation – lung retransplantation – chronic lung allograft dysfunction – fundoplication for CLAD

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(Další odkazy na literaturu jsou dostupné ve webové verzi článku na www.perspinsurg.com).

MUDr. René Novysedlák
Národní program transplantace plic
pro Českou a Slovenskou republiku
III. chirurgická klinika 1. LF UK a FN v Motole
e-mail: rene.novysedlak@fnmotol.cz
ORCID: 0000-0002-2660-6815

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