#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Thyroid surgery in children: our experience


Authors: P. Zahradnikova 1;  L. Fědorová 1;  J. Babala 1;  I. Béder 1;  J. Staník 3,4;  R. Králik 2
Authors‘ workplace: Klinika detskej chirurgie Lekárskej fakulty Univerzity Komenského a Národný ústav detských chorôb, Bratislava 1;  Klinika onkologickej chirurgie Lekárskej Univerzity Komenského a Onkologický ústav sv. Alžbety, Bratislava 2;  Detská klinika Lekárskej Univerzity Komenského a Národný ústav detských chorôb, Bratislava 3;  Inštitút experimentálnej endokrinológie, Biomedicínske centrum Slovenskej akadémie vied, Bratislava 4
Published in: Rozhl. Chir., 2021, roč. 100, č. 1, s. 21-26.
Category: Original articles
doi: https://doi.org/10.33699/PIS.2021.100.1.21–26

Overview

Introduction: Thyroid surgery in children is a rare operation. The aim of our paper is to point out the specifics of thyroid surgery in children.

Methods: Retrospective analysis of patients hospitalized at the Department of Paediatric Surgery, Faculty of Medicine, Comenius University and National Institute of Children’s Diseases in Bratislava during a 10-year period (2007−2016) who underwent thyroid surgeries.

Results: The retrospective analysis included 81 patients: 66 (81%) girls and 15 (19%) boys. The mean age of the patients was 14 years ±8 months (range 4−18 years). The most common indications for thyroid surgery were: a nodule in 36 (44.4%) patients, Graves Basedow thyrotoxicosis in 19 (23.5%) patients, and suspected thyroid carcinoma in 11 (13.6%) patients. Cervical lymph node metastases (mts) were diagnosed in 9 (11.1%) patients, and distant pulmonary metastases in 5 (6.17%) patients. Total thyroidectomy (TTE) was performed in 43 (53%) patients, total lobectomy (TL) in 20 (24.7%) patients. Extended surgery on regional lymph nodes was performed in 9 (11.1%) patients. Eight (9.9%) patients underwent reoperation. A total of 12 (14.8%) patients experienced postoperative complications. Unilateral transient recurrent laryngeal nerve (RLN) paralysis occurred in 2 patients, and permanent in one patient. Transient postoperative hypoparathyroidism with hypocalcaemia was reported in 8 (9.9%) patients; no permanent condition of this type was observed.

Conclusion: Multidisciplinary collaboration ensures that optimal surgical results are achieved in the patients. Experience of the surgeon performing thyroid surgery in children remains crucial.

Keywords:

thyroid gland − thyroid carcinoma – thyroidectomy − NLR paresis − node in children


Sources
  1. Popoveniuc G, Jonklaas J. Thyroid nodules. Med Clin North Am. 2012;96(2):329−349. doi:10.1016/j.mcna.2012.02.002.
  2. Safranek J, Treska V, Skalicky T, et al. [Thyroid carcinoma, ten-years file.] [in Czech]. Rozhl Chir. 95(11):394−397.
  3. Choi H, Kasaian K, Melck A, et al. Papillary thyroid carcinoma: prognostic significance of cancer presentation. Am J Surg. 2015;210(2):298−301. doi:10.1016/j.amjsurg.2014.12.047.
  4. Carty, David S. Cooper, Gerard M. Doherty, et al. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid 2009;19(11):1153−1158. doi:10.1089/thy.2009.0159.
  5. Cooper DS, Doherty GM, Haugen BR, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2006;16(2):109−142. doi:10.1089/thy.2006.16.109.
  6. Welch Dinauer CA, Tuttle RM, Robie DK, et al. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clin Endocrinol. (Oxf) 1998;49(5):619−628. doi:10.1046/j.1365-2265.1998.00584.x.
  7. Feinmesser R, Lubin E, Segal K, et al.  Carcinoma of the thyroid in children--a review. J Pediatr Endocrinol Metab. 1997;10(6):561−568. doi:10.1515/jpem.1997.10.6.561.
  8. Vassilopoulou-Sellin R, Klein MJ, Smith TH, et al. Pulmonary metastases in children and young adults with differentiated thyroid cancer. Cancer. 1993;71(4):1348−1352. doi:10.1002/1097-0142(19930215)71:4<1348::aid-cncr2820710429>3.0.co;2-3.
  9. Francis GL, Waguespack SG, Bauer AJ, et al. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015;25(7):716−759. doi:10.1089/thy.2014.0460.
  10. Patel NA, Bly RA, Adams S, et al. A clinical pathway for the postoperative management of hypocalcemia after pediatric thyroidectomy reduces blood draws. Int J Pediatr Otorhinolaryngol. 2018;105:132−137. doi:10.1016/j.ijporl.2017.12.011.
  11. Sosa JA, Bowman HM, Tielsch JM, et al. The importance of surgeon experience for clinical and economic outcomes from thyroidectomy. Ann Surg. 1998;228(3):320−330. doi:10.1097/00000658-199809000-00005.
  12. Savio R, Gosnell J, Palazzo FF, et al. The role of a more extensive surgical approach in the initial multimodality management of papillary thyroid cancer in children. J Pediatr Surg. 2005;40(11):1696−1700. doi:10.1016/j.jpedsurg.2005.07.029.
  13. Babala J, Zahradnikova P, Beder I, et al. Risk factors of post-surgery complications in children with thyroid cancer. Int J Pediatr Otorhinolaryngol. 2019;106:109. doi.10.1016/j.ijporl.2019.109673.
  14. Piciu D, Piciu A, Irimie A. Thyroid cancer in children: a 20-year study at a Romanian oncology institute. Endocr J. 2012;59(6):489−496. doi:10.1507/endocrj.ej11-0397.
  15. Demidchik YE, Demidchik EP, Reiners C, et al. Comprehensive clinical assessment of 740 cases of surgically treated thyroid cancer in children of Belarus. Ann Surg. 2006;243(4):525−532. doi.10.1097/01.sla.0000205977.74806.0b.
  16. Powers PA, Dinauer CA, Tuttle RM, et al. Tumor size and extent of disease at diagnosis predict the response to initial therapy for papillary thyroid carcinoma in children and adolescents. J Pediatr Endocrinol Metab. 2003;16(5):693−702. doi:10.1515/jpem.2003.16.5.693.
  17. Buffet C, Golmard JL, Hoang C, et al. Scoring system for predicting recurrences in patients with papillary thyroid microcarcinoma. Eur J Endocrinol. 2012;167(2):267−275. doi:10.1530/EJE-12-0105.
  18. Leboulleux S, Girard E, Rose M, Travagli JP, et al. Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer. J Clin Endocrinol Metab. 2007;92(9):3590−3594. doi:10.1210/jc.2007-0444.
  19. Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab. 2002;87(5):1941−1946. doi:10.1210/jcem.87.5.8504.
  20. De Jong SA. Thyroid cancer: A comprehensive guide to clinical management. Arch Pathol Lab Med. 2000;124(9):1391−1396.
  21. Bongiovanni M, Bellevicine C, Troncone G, et al. Approach to cytological indeterminate thyroid nodules. Gland Surg. 2019;8:98−104. doi:10.21037/gs.2018.12.06.
  22. Baloch ZW, Tam D, Langer J, et al. Ultrasound-guided fine-needle aspiration biopsy of the thyroid: role of on-site assessment and multiple cytologic preparations. Diagn Cytopathol. 2000;23(6):425−429. doi:10.1002/1097-0339(200012)23:6<425::aid-dc14>3.0.co;2-3.
  23. Hodax JK, Bowerman K, Quintos JB. Benign thyroid nodules in pediatric patients: determining best practices for repeat ultrasound evaluations. J Pediatr Endocrinol Metab. 2019;32(8):895−901. doi:10.1515/jpem-2018-0476.
  24. Kizilgul M, Shrestha R, Radulescu A, et al. Thyroid nodules over 4 cm do not have higher malignancy or benign cytology false-negative rates. Endocrine. 2019;66(2):249−253. doi.10.1007/s12020-019-01964-3.
  25. Bussieres V, Roy S, Deladoey J, et al. Pediatric thyroidectomy: Favorable outcomes can be achieved by a multidisciplinary team of pediatric providers. J Pediatr Surg. 2019;54(3):527−530. doi:10.1016/j.jpedsurg.2018.06.029.
  26. Sosa JA, Tuggle CT, Wang TS, et al. Clinical and economic outcomes of thyroid and parathyroid surgery in children. J Clin Endocrinol Metab. 2008;93(8):3058–3065. doi:10.1210/jc.2008-0660.
  27. Breuer C, Tuggle C, Solomon D, et al. Pediatric thyroid disease: when is surgery necessary, and who should be operating on our children? J Clin Res Pediatr Endocrinol. 2013;5 Suppl 1:79−85. doi:10.4274/jcrpe.817.
  28. Lacoste L, Gineste D, Karayan J, et al. Airway complications in thyroid surgery. Ann Otol Rhinol Laryngol. 1993;102(6):441−446. doi:10.1177/000348949310200607.
  29. Farooq MS, Nouraei R, Kaddour H, et al. Patterns, timing and consequences of post-thyroidectomy haemorrhage. Ann R Coll Surg Engl. 2017;99(1):60−62. 10.1308/rcsann.2016.0270.
  30. Meyer T, Hocht B. Recurrent laryngeal nerve monitoring during thyroid surgery in childhood. Eur J Pediatr Surg. 2006;16(3):149−154. doi:10.1055/s-2006-924219.
  31. Schneider R, Machens A, Sekulla C, et al. Twenty-year experience of paediatric thyroid surgery using intraoperative nerve monitoring. Br J Surg. 2018;105(8):996−1005. doi:10.1002/bjs.10792.
Labels
Surgery Orthopaedics Trauma surgery

Article was published in

Perspectives in Surgery

Issue 1

2021 Issue 1

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#