Horn F., Martinka I., Fuňáková M., Šabová L., Drdulová T., Hornová J., Trnka J.: Epidemiology of Neural Tube Defects


Authors: F. Horn;  I. Martinka 1;  M. Fuňáková;  L. Šabová 2;  T. Drdulová 3;  J. Hornová 4;  J. Trnka
Authors‘ workplace: Klinika detskej chirurgie LF UKo a DFNsP, Bratislava, Slovenská republika, prednosta: doc. MUDr. J. Trnka, PhD. ;  Neurologická klinika, Fakultná nemocnica Ružinov, Bratislava, Slovenská republika, prednosta: Prof. MUDr. Ľ. Lisý, DrSc. 1;  II. detská klinika LF UKo a DFNsP, Bratislava, Slovenská republika, prednosta: prof. MUDr. L. Kovács, DrSc. 2;  Slovenská spoločnosť pre spina bifida a/alebo hydrocefalus, o. z. 3;  I. detská klinika LF UKo a DFNsP, Bratislava, Slovenská republika, prednosta: doc. MUDr. O. Červeňová, PhD. 4
Published in: Rozhl. Chir., 2011, roč. 90, č. 5, s. 259-263.
Category: Monothematic special - Original

Overview

Introduction:
Neural tube defects represent group of congenital diseases with relatively high incidence in population. Authors assess world and Slovak literature and statistical facts about the epidemiology of NTD and compare them with their own results of retrospective study performed in Children’s Hospital, Bratislava.

Materials and methods:
List of patients consists of 250 children (106 boys, 144 girls): X-ray images showing lumbo-sacral part of vertebral column were evaluated retrospectively (X-ray of native abdomen, urological tract or skeleton). Authors assessed presence or non-presence of spina bifida on images, without relation to age, gender or diagnosis of patients.

Results:
From the total number of 250 radiograms, 72 findings were positive (36 boys and 36 girls), 160 images were negative, 18 were unsuitable for evaluation due to low image quality. The highest diagnostic capture was from urological images – 40% of all positive findings. Incidence of spina bifida in Children’s Hospital concluded from X-ray images is quite high – 28.8%.

Conclusion:
According to the data from National Centre of Health Statistics the incidence of open caudal neural tube defects in Slovakia is under 5 per 10 000 live-born children at present time. However the occurrence of occult spina bifida is not known exactly. The high rate of spina bifida presented herein (28%) can be caused by relatively low number of evaluated radiograms. Also the fact that children were not only healthy ones and data were obtained from the western part of Slovakia as well. In conclusion we can say that after accidental finding of caudal neural tube defect consecutive diagnostics should be performed in clinical positive cases – genetics, MRI and consultation with specialists to decide for the optimal follow up of the patient.

Key words:
neural tube defects – occult spina bifida – epidemiology


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