-
Medical journals
- Career
Preoperative diagnosis of salivary gland tumors
Authors: M. Hyravý 1; Ivo Stárek 1; R. Salzman 1; P. Beláková 1; J. Čivrný 2
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF UP a FN Olomouc 1; Radiologická klinika LF UP a FN Olomouc 2
Published in: Otorinolaryngol Foniatr, 75, 2026, No. 2, pp. 127-139.
Category: Review Article
doi: https://doi.org/10.48095/ccorl2026127Overview
Salivary gland tumors represent a heterogeneous group of diseases with a wide spectrum of biological behavior. Preoperative diagnosis plays a crucial role in determining the appropriate therapeutic strategy and has a significant impact on surgical planning as well as overall patient prognosis. Despite advances in diagnostic modalities, distinguishing between benign and malignant lesions before surgery remains a challenge in many cases. Accurate preoperative assessment typically requires a combination of imaging, cytohistological, and clinical methods, and is characterized by a multidisciplinary approach. Ultrasound examination complemented by fine-needle aspiration biopsy is currently considered the standard diagnostic tool in the evaluation of salivary gland tumors. However, due to its limitations, additional methods are often employed to objectively assess the extent of disease and to determine the biological nature of the tumor, including its precise histopathological classification. This article aims to present the current possibilities in the preoperative diagnostic work-up of salivary gland tumors, with an emphasis on the benefits and limitations of various approaches in the context of therapeutic planning. Special attention is given to the reliability of preoperative prediction of tumor behavior and its potential invasiveness, both of which are critical factors influencing the extent of surgery and the need for further oncological treatment. A thorough understanding of this diagnostic process forms the basis for rational indication of paraclinical examinations in the management of salivary gland neoplasms.
Keywords:
diagnosis – neoplasms – salivary glands
Sources
1. Stárek I, Salzman R, Skálová A et al. Doporučené postupy v diagnostice a léčbě nádorů příušní žlázy. Otorinolaryngol Foniatr 2017; 66 (3): 119–126.
2. Rajbhar R, Ekatpure D, Kolhe A. Comprehensive five-year study on salivary gland tumors: Demographic, clinical, and histopathological insights. Adv Oral Maxillofac Surg 2025; 17 : 100523. Doi: 10.1016/j.adoms.2025.100523.
3. Westergaard-Nielsen M, Godballe C, Eriksen JG et al. Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. Eur Arch Otorhinolaryngol 2020; 277 : 2901–2908. Doi: 10.1007/s00405-020-06205-2
4. Tian Z, Li L, Wang L et al. Salivary gland neoplasms in oral and maxillofacial regions: a 23--year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 2010; 39 (3): 235–242. Doi: 10.1016/j.ijom.2009.10.016.
5. Sentani K, Ogawa I, Ozasa K et al. Characteristics of 5015 salivary gland neoplasms registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. J Clin Med 2019; 8 (5): 566. Doi: 10.3390/jcm8050566.
6. Gontarz M, Bargiel J, Gąsiorowski K et al. Epidemiology of primary epithelial salivary gland tumors in southern Poland – a 26-year, clinicopathologic, retrospective analysis. J Clin Med 2021; 10 (8): 1663. Doi: 10.3390/jcm10081663.
7. Alsanie I, Rajab S, Cottom H et al. Distribution and frequency of salivary gland tumours: an international multicenter study. Head Neck Pathol 2022; 16 (4): 1043–1054. Doi: 10.1007/s12105-022-01459-0.
8. Gatta G, Guzzo M, Locati LD et al. Major and minor salivary gland tumours. Crit Rev Oncol Hematol 2020; 152 : 102959. Doi: 10.1016/j.critrevonc.2020.102959.
9. WHO Classification of Tumours Editorial Board. Head and neck tumours. WHO classification of tumours. 5th ed. Vol. 9. Lyon: International Agency for Research on Cancer 2022. 2022 [online]. Dostupné z: https: //publications.iarc.fr/.
10. Franzen AM, Kaup Franzen C, Guenzel T et al. Increased incidence of Warthin tumours of the parotid gland: a 42 year evaluation. Eur Arch Otorhinolaryngol 2018; 275 (10): 2593–2598. Doi: 10.1007/s00405-018-5092-3.
11. Yanes Diaz J, Riestra Ayora J, Rodriguez Rivero A et al. Trend changes in the incidence of benign parotid tumours in the last 30 years in a Spanish population. Eur Arch Otorhinolaryngol 2023; 280 (2): 855–860. Doi: 10.1007/s00405-022-07644-9.
12. Żurek M, Rzepakowska A, Jasak K et al. The epidemiology of salivary glands pathologies in adult population over 10 years in Poland – cohort study. Int J Environ Res Public Health 2022; 19 (1): 179. Doi: 10.3390/ijerph19010179.
13. Modrić A, Gabelica M, Mihovilović A et al. Eleven year incidence of salivary gland tumors – a retrospective, single centered study in Croatia. Clin Pract 2025; 15 (6): 104. Doi: 10.3390/clinpract15060104.
14. Nachtsheim L, Mayer M, Meyer MF et al. Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10 year data from a population based state cancer registry in Germany. J Cancer Res Clin Oncol 2023; 149 (7): 3811–3821. Doi: 10.1007/s00432-022-04278-6.
15. Krejčí D, Májek T, Dušek L et al. Zhoubné nádory velkých slinných žláz za období 2010–2021. Zdroj NOR. 2022 [online] Dostupné z: https: //drive.google.com/file/d/1el5MMJ7b_tIUeUSgjYzgbJYK9AWBpdv2/view.
16. Lombardi D, McGurk M, Vander Poorten V et al. Surgical treatment of salivary malignant tumors. Oral Oncol 2017; 65 : 102–113. Doi: 10.1016/j.oraloncology.2016.12.007.
17. van Herpen C, Vander Poorten V, Skalova A et al. Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) clinical practice guideline for diagnosis, treatment and follow-up. ESMO Open 2022; 7 (6): 100602. Doi: 10.1016/j.esmoop.2022.100602.
18. Amit M, Binenbaum Y, Trejo-Leider L et al. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck. Head Neck 2015; 37 (7): 1038–1045.
19. Chen AM, Bucci MK, Weinberg V et al. Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: prognostic features of recurrence. Int J Radiat Oncol Biol Phys 2006; 66 (1): 152–159.
20. Eom HJ, Lee JH, Ko MS et al. Comparison of fine-needle aspiration and core needle biopsy under ultrasonographic guidance for detecting malignancy and for the tissue-specific diagnosis of salivary gland tumors. AJNR Am J Neuroradiol 2015; 36 (6): 1188–1193. Doi: 10.3174/ajnr.A4247.
21. Archondakis S, Roma M, Kaladelfou E. Two-year experience of the implementation of the Milan for Reporting Salivary Gland Cytopathology at a private medical laboratory. Head Neck Pathol 2021; 15 (3): 780–786. Doi: 10.1007/s12105-020-01278-1.
22. Gubbiotti MA, Jalaly J, Baloch Z. Making a case for the success of Milan system for reporting salivary gland cytopathology. Diagn Cytopathol 2022; 50 (9): 451–455. Doi: 10.1002/dc.25010.
23. Tommola E, Kalfert D, Hakso Mäkinen H et al. The contributory role of cell blocks in salivary gland neoplasms fine needle aspirations classified by the Milan System for Reporting Salivary Gland Cytology. Diagnostics 2021; 11 (10): 1778. Doi: 10.3390/diagnostics11101778.
24. Chen YA, Wu CY, Yang CS. Application of the Milan system for reporting salivary gland cytopathology: a retrospective study in a tertiary institute. Diagn Cytopathol. 2019; 47 (11): 1160–1167. Doi: 10.1002/dc.24279.
25. Lee JJL, Tan HM, Chua DYS et al. The Milan system for reporting salivary gland cytology: a retrospective analysis of 1384 cases in a tertiary Southeast Asian institution. Cancer Cytopathol 2020; 128 (5): 348–358. Doi: 10.1002/cncy.22245.
26. Vallonthaiel AG, Kaushal S, Jangir H et al. Application of the Milan system for risk stratification and its comparison with a previous reporting system of parotid gland cytopathology in a tertiary care centre. Acta Cytol 2018; 62 (5–6): 352–359. Doi: 10.1159/000492051.
27. Dostálová L, Kalfeřt D, Jechová A et al. The role of fine needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls. Eur Arch Otorhinolaryngol 2020; 277 (6): 1763–1769. Doi: 10.1007/s00405-020-05868-1.
28. Ahn S, Kim Y, Oh YL. Fine needle aspiration cytology of benign salivary gland tumors with myoepithelial cell participation: an institutional experience of 575 cases. Acta Cytol 2013; 57 (6): 567–574.
29. Hughes JH, Volk EE, Wilbur DC. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in nongynecologic cytology. Arch Pathol Lab Med 2005; 129 (1): 26–31.
30. Novoa E, Gurtler N, Arnoux A et al. Diagnostic value of core needle biopsy and fine needle aspiration in salivary gland lesions. Head Neck 2016; 38: E346–E352. Doi: 10.1002/hed.23999.
31. Colella G, Cannavale R, Flamminio F et al. Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg 2010; 68 (9): 2146–2153.
32. Liu CC, Jethwa AR, Khariwala SS et al. Sensitivity, specificity, and posttest probability of parotid fine-needle aspiration: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2016; 154 (1): 9–23. Doi: 10.1177/0194599815607841.
33. Griffith CC, Pai RK, Schneider F et al. Salivary gland tumor fine needle aspiration cytology: a proposal for a risk stratification classification. Am J Clin Pathol 2015; 143 (6): 839–853. Doi: 10.1309/AJCPMII6OSD2HSJA.
34. Rossi ED, Wong LQ, Bizzarro T et al. The impact of FNAC in the management of salivary gland lesions: institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol 2016; 124 (6): 388–396. Doi: 10.1002/cncy.21710.
35. Maleki Z, Miller JA, Arab SE et al. “Suspicious” salivary gland FNA: risk of malignancy and interinstitutional variability. Cancer Cytopathol 2018; 126 (2): 94–100. Doi: 10.1002/cncy.21939.
36. Wang H, Malik A, Maleki Z et al. “Atypical” salivary gland fine needle aspiration: risk of malignancy and interinstitutional variability. Diagn Cytopathol 2017; 45 (12): 1088–1094. Doi: 10.1002/dc.23826.
37. Kala C, Kala S, Khan L. Milan system for reporting salivary gland cytopathology: an experience with the implication for risk of malignancy. J Cytol 2019; 36 (3): 160–166. Doi: 10.4103/JOC.JOC165_18.
38. Rossi ED, Baloch Z, Barkan G et al. The Milan system for reporting salivary gland cytopathology: refining the role of salivary gland FNA. Cancer Cytopathol 2024; 132 (1): 10–21. Doi: 10.1002/cncy.22753.
39. Zurrida S, Alasio L, Tradati N et al. Fine-needle aspiration of parotid masses. Cancer 1993; 72 (8): 2306–2311. Doi: 10.1002/1097-0142 (19931015) 72 : 8<2306:: aid-cncr2820720804>3.0.co; 2-e.
40. He Y, Zhang ZY, Tian Z. The diagnostic value of fine-needle aspiration cytology (FNAC) for lesions in the parotid gland. Shanghai Kou Qiang Yi Xue 2003; 12 : 410–413.
41. Hajiioannou J, Gkrinia E, Brotis GA et al. Diagnostic accuracy of fine needle aspiration cytology in parotid gland lesions. Hippokratia 2022; 26 (1): 25–31.
42. Chrabanska M, Kiczmer P, Drozdowska B. Salivary gland lesions: diagnostic reliability and challenges of fine needle aspiration cytology. Int J Clin Exp Pathol 2021; 14 (1): 54–62.
43. Ashraf A, Shaikh AS, Kamal F et al. Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol 2010; 38 (7): 499–504. Doi: 10.1002/dc.21211.
44. Osanai H, Osaki T, Nonaka S et al. Parotid tumors: clinical study of 36 cases. Prac Otorhinolaryngol 2003; 96 (12): 799–804. Doi: 10.5631/jibirin.96.799.
45. Aversa S, Ondolo C, Bollito E et al. Preoperative cytology in the management of parotid neoplasms. Am J Otolaryngol 2006; 27 (2): 96–100. Doi: 10.1016/j.amjoto.2005.07.015.
46. Schroder U, Eckel HE, Rasche V et al. Value of fine needle puncture cytology in neoplasms of the parotid gland. HNO 2000; 48 (6): 421–429. Doi: 10.1007/s001060050592.
47. Al Salamah SM, Khalid K, Khan IA et al. Outcome of surgery for parotid tumours: 5-year experience of a general surgical unit in a teaching hospital. ANZ J Surg 2005; 75 (11): 948–952. Doi: 10.1111/j.1445-2197.2005.03580.x.
48. Schmidt RL, Hall B, Wilson AR et al. A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol 2011; 136 (1): 45–59. Doi: 10.1309/AJCPOIE0CZNAT6SQ.
49. Huang YC, Wu CT, Lin G et al. Comparison of ultrasonographically guided fine-needle aspiration and core needle biopsy in the diagnosis of parotid masses. J Clin Ultrasound 2012; 40 (4): 189–194.
50. Pfeiffer J, Ridder GJ, Diagnostic value of ultrasound-guided core needle biopsy in patients with salivary gland masses. Int J Oral Maxillofac Surg 2012; 41 (4): 437–443. Doi: 10.1016/j.ijom.2011.12.005.
51. Buckland JR, Manjaly G, Violaris N et al. Ultrasound-guided cutting-needle biopsy of the parotid gland. J Laryngol Otol 1999; 113 (11): 988–992. Doi: 10.1017/s0022215100145785.
52. Kesse KW, Manjaly G, Violaris N et al. Ultrasound-guided biopsy in the evaluation of focal lesions and diffuse swelling of the parotid gland. Br J Oral Maxillofac Surg 2002; 40 (5): 384–388.
53. Howlett DC, Menezes LJ, Lewis K et al. Sonographically guided core biopsy of a parotid mass. AJR Am J Roentgenol 2007; 188 (1): 223–227. Doi: 10.2214/AJR.05.1549.
54. Wan YL, Chan SC, Chen YL et al. Ultrasonography-guided core-needle biopsy of parotid gland masses. AJNR Am J Neuroradiol 2004; 25 (9): 1608–1612.
55. Cho J, Kim J, Lee JS et al. Comparison of core needle biopsy and fine-needle aspiration in diagnosis of malignant salivary gland neoplasm: systematic review and meta-analysis. Otolaryngol Head Neck Surg 2021; 165 (3): 379–387. Doi: 10.1177/0194599821999640.
56. Heidari F, Heidari F, Rahmaty B et al. The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration. Am J Otolaryngol 2020; 41 : 102718. Doi: 10.1016/j.amjoto.2020.102718.
57. The determination of specificity, sensitivity and accuracy of core needle biopsy in the diagnosis of parotid and submandibular salivary glands tumors. Vojnosanit Pregl 2019; 76 : 921–928. Doi: 10.2298/VSP170320001O.
58. Del Cura JL, Coronado G, Zabala R et al. Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands. Eur Radiol 2018; 28 : 2934–2941. Doi: 10.1007/s00330-017-5295-9.
59. Walsh E, Allan K, Brennan PA et al. Diagnostic accuracy of ultrasonography-guided core needle biopsy of parotid gland neoplasms: a large, single-institution experience in United Kingdom. Oral Pathol Med 2022; 51 (1): 1–4. Doi: 10.1111/jop.13260.
60. Cengiz AB, Tansuker HD, Gul R et al. Comparison of preoperative diagnostic accuracy of fine needle aspiration and core needle biopsy in parotid gland neoplasms. Eur Arch Otorhinolaryngol 2022; 279 : 527–533. Doi: 10.1007/s00405-021-07022-x.
61. Hurry KJ, Karunaratne D, Westley S et al. Ultrasound-guided core biopsy in the diagnosis of parotid neoplasia: an overview and update with a review of the literature. Br J Radiol 2022; 95 (1130): 20210972. Doi: 10.1259/bjr.20210972.
62. Boldes T, Hilly O, Alkan U et al. Accuracy, predictability and prognostic implications of fine-needle aspiration biopsy for parotid gland tumours: a retrospective case series. Clin Otolaryngol 2021; 46 : 1065–1072. Doi: 10.1111/coa.13795.
63. Lanišnik B, Levart P, Čizmarevič B et al. Surgeon-performed ultrasound with fine-needle aspiration biopsy for the diagnosis of parotid gland tumors. Head Neck 2021; 43 : 1739–1746. Doi: 10.1002/hed.26630.
64. Seyhun N, Doğan U, Çalış ZAB et al. The role of fine needle aspiration biopsy in deep lobe parotid tumors: comparison of preoperative cytology and postoperative histopathologic results. Am J Otolaryngol 2021; 42 : 102590. Doi: 10.1016/j.amjoto.2020.102590.
65. Galli A, Tulli M, Giordano L et al. Fine needle aspiration cytology for parotid neoplasms: risk of malignancy through inconclusive results and lower grade tumors. Eur Arch Otorhinolaryngol 2020; 277 : 841–851. Doi: 10.1007/s00405-019-05733-w.
66. Shah KSV, Ethunandan M. Tumour seeding after fine-needle aspiration and core biopsy of the head and neck – a systematic review. Br J Oral Maxillofac Surg 2016; 54 (3): 260–265. Doi: 10.1016/j.bjoms.2016.01.004.
67. Ultrasound-guided core needle biopsy of salivary gland lesions: a systematic review. Laryngoscope 2014; 124 (3): 695–700. Doi: 10.1002/lary.24339.
68. Ahuja AT, Evans RM, Valantis AC. Salivary gland cancer. In: Imaging in head and neck cancer. London: Greenwich Medical Media 2003 : 115–141.
69. Burke CJ, Thomas RH, Howlett D. Imaging the major salivary glands. Br J Oral Maxillofac Surg 2011; 49 (4): 261–269. Doi: 10.1016/j.bjoms.2010.03.002.
70. Neither MRI, CT nor US is superior to diagnose tumors in the salivary glands – an extended case study. Head Face Med 2007; 3 : 19. Doi: 10.1186/1746-160X-3-19.
71. Heřman J, Sedláčková Z, Vachutka J et al. Differential diagnosis of parotid gland tumors: role of shear wave elastography. Biomed Res Int 2017; 2017 : 9234672. Doi: 10.1155/2017/9234672.
72. Cantisani V, David E, De Virgilio A et al. Prospective evaluation of quasistatic ultrasound elastography compared with baseline US for parotid gland lesions: preliminary results of elasticity contrast index evaluation. Med Ultrason 2017; 19 (1): 32–38. Doi: 10.11152/mu923.
73. Wu S, Liu G, Chen R et al. Role of ultrasound in the assessment of benignity and malignancy of parotid masses. Dentomaxillofac Radiol 2012; 41 (2): 131–135. Doi: 10.1259/dmfr/60907848.
74. Dibbad RB, Diwanji NS, Dasar SK et al. The role of grey scale and color Doppler ultrasound in evaluation and differentiation of major salivary gland lesions. Int J Anat Radiol Surg 2018; 7 (1): RO11–RO17. Doi: 10.7860/IJARS/2018/29365.2354.
75. Dumitriu DI, Badea RI, Jid CB et al. B-mode and color Doppler ultrasound features of salivary gland tumors. Med Ultrason 2008; 8 (1): 31–37.
76. Jiang LP. Characteristics of pleomorphic adenomas, adenolymphomas, and malignant tumors of the salivary glands on color Doppler ultrasonography and contrast enhanced ultrasonography. Eur Rev Med Pharmacol Sci 2020; 24 (22): 11509–11517. Doi: 10.26355/eurrev_202011_23792.
77. Strympl P, Kodaj M, Bakaj T. Color Doppler ultrasound in the pre-histological determination of the biological character of major salivary gland tumors. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014; 158 (3): 465-469. Doi: 10.5507/bp.2012.074.
78. Heřman J, Sedláčková Z, Furt T. The role of ultrasound and shear-wave elastography in evaluation of cervical lymph nodes. Biomed Res Int 2019; 2019 : 4318251. Doi: 10.1155/2019/4318251.
79. Dumitriu D, Dudea S, Botar-Jid C. Real-Time Sonoelastography of Major Salivary Gland Tumors. AJR Am J Roentgenol 2011; 197 (5): W924-30. Doi: 10.2214/AJR.11.6529.
80. Matsuda E, Fukuhara T, Donishi R et al. Clinical utility of qualitative elastography using acoustic radiation force impulse for differentiating benign from malignant salivary gland tumors. Ultrasound Med Biol 2021; 47 (2): 279–287. Doi: 10.1016/j.ultrasmedbio.2020.10.007.
81. Wu J, Zhou Z, Wang X et al. Diagnostic performance of elastosonography in the differential diagnosis of benign and malignant salivary gland tumors. Front Oncol 2022; 12 : 954751. Doi: 10.3389/fonc.2022.954751.
82. Thoeny HC. Imaging of salivary gland tumours. Cancer Imaging 2007; 7 (1): 52–62. Doi: 10.1102/1470-7330.2007.0008.
83. Liu Y, Li J, Tan Y et al. Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 119 (2): 238-245.e2. Doi: 10.1016/j.oooo.2014.10.020.
84. Kong X, Li H, Han Z. The diagnostic role of ultrasonography, computed tomography, magnetic resonance imaging, positron emission tomography/computed tomography, and real-time elastography in the differentiation of benign and malignant salivary gland tumors: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 2019; 128 (4): 431–443.e1. Doi: 10.1016/j.oooo.2019.06.014.
85. Maraghelli D, Pietragalla M, Cordopatri C et al. Magnetic resonance imaging of salivary gland tumours: key findings for imaging characterisation. Eur J Radiol 2021; 140 : 109716. Doi: 10.1016/j.ejrad.2021.109716.
86. Friedman E, Patino MO, Abdel Razek AA et al. MR imaging of salivary gland tumors. Magn Reson Imaging Clin N Am 2022; 30 (1): 135-149. Doi: 10.1016/j.mric.2021.07.006.
87. Yousem DM, Kraut MA, Chalian AA. Major salivary gland imaging. Radiology 2000; 216 (1): 19-29. Doi: 10.1148/radiology.216.1.r00jl4519.
88. Khamis MEM, Ahmed AF, Ismail EI et al. The diagnostic efficacy of apparent diffusion coefficient value and Choline/Creatine ratio in differentiation between parotid gland tumors. Egyptian J Radiol Nucl Med 2018; 49 (2): 358-367. Doi: 10.1016/j.ejrnm.2018.02.004.
89. Zhang W, Zuo Z, Luo N et al. Non-enhanced MRI in combination with color Doppler flow imaging for improving diagnostic accuracy of parotid gland lesions. Eur Arch Otorhinolaryngol 2018; 275 (4): 987–995. Doi: 10.1007/s00405-018-4895-6.
90. Milad P, Albegiermy M, Shokry T et al. The added value of pretreatment DW MRI in characterization of salivary glands pathologies. Am J Otolaryngol 2017; 38 (1): 13–20. Doi: 10.1016/j.amjoto.2016.09.002.
91. Razek AAKA, Samir S, Ashmalla A. Characterization of parotid tumors with dynamic susceptibility contrast perfusion-weighted magnetic resonance imaging and diffusion-weighted MR imaging. J Comput Assist Tomogr 2017; 41 (1): 131–136. Doi: 10.1097/RCT.0000000000000486.
92. Tao X, Yang G, Wang P et al. The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours. Dentomaxillofac Radiol 2017; 46 (6): 20160434. Doi: 10.1259/dmfr.20160434.
93. Yuan Y, Tang W, Tao X. Parotid gland lesions: separate and combined diagnostic value of conventional MRI, diffusion-weighted imaging and dynamic contrast-enhanced MRI. Br J Radiol 2016; 89 (1060): 20150912. Doi: 10.1259/bjr.20150912.
94. Celebi I, Mahmutoglu AS, Ucgul A et al. Quantitative diffusion-weighted magnetic resonance imaging in the evaluation of parotid gland masses: a study with histopathological correlation. Clin Imaging 2013; 37 (2): 232 238. Doi: 10.1016/j.clinimag.2012.04.025.
95. İnci EHE, Hocaoglu E, Kilickesmez O et al. Quantitative diffusion weighted MR imaging in the differential diagnosis of parotid gland tumors: is it a useful technique? Turkiye Klinikleri J Med Sci 2010; 30 (4): 1339 1345. Doi: 10.5336/medsci.2009 14994.
96. Eida S, Sumi M, Sakihama N et al. Apparent diffusion coefficient mapping of salivary gland tumors: prediction of the benignancy and malignancy. AJNR Am J Neuroradiol 2007; 28 (1): 116 121. Doi: 10.3174/ajnr.28.1.116.
97. Zhang W, Zuo Z, Huang X et al. Value of Diffusion-Weighted Imaging Combined with Susceptibility-Weighted Imaging in Differentiating Benign from Malignant Parotid Gland Lesions Med Sci Monit 2018, 4 (24): 4610-4616. Doi: 10.12659/MSM.911185.
98. Habermann CR, Arndt C, Graessner J et al. Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol 2009; 30 (3): 591–596. Doi: 10.3174/ajnr.A1412.
99. Matsushima N, Maeda M, Takamura M et al. Apparent diffusion coefficients of benign and malignant salivary gland tumors. Comparison to histopathological findings. J Neuroradiol 2007; 34 (3): 183–189. Doi: 10.1016/j.neurad.2007.04.002.
100. Yologlu Z, Aydin H, Alp NA et al. Diffusion weighted magnetic resonance imaging in the diagnosis of parotid masses: preliminary results. Saudi Med J 2016; 37 (12): 1412–1416. Doi: 10.15537/smj.2016.12.16288.
101. Sumi M, Van Cauteren M, Sumi T et al. Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology 2012; 263 (3): 770–777. Doi: 10.1148/radiol.12111248.
102. Yu J, Huang H, Gao J et al. Intravoxel incoherent motion and diffusion kurtosis imaging for subtype differentiation in salivary gland tumors: a diagnostic performance study. BMC Med Imaging 2025; 25 (1): 319. Doi: 10.1186/s12880-025-01815-w.
103. Zhang R, King AD, Wong LM et al. Discriminating between benign and malignant salivary gland tumors using diffusion-weighted imaging and intravoxel incoherent motion at 3 Tesla. Diagn Interv Imaging 2023; 104 (2): 67–75. Doi: 10.1016/j.diii.2022.08.003.
104. Hisatomi M, Asaumi J, Yanagi Y et al. Diagnostic value of dynamic contrast-enhanced MRI in salivary gland tumors. Oral Oncol 2007; 43 (9): 940–947. Doi: 10.1016/j.oraloncology. 2006.11.009.
105. Hisatomi M, Asaumi J, Yanagi Y et al. Assessment of pleomorphic adenomas using MRI and dynamic contrast-enhanced MRI. Oral Oncol 2003; 39 (6): 574–579. Doi: 10.1016/s13 68-8375 (03) 00040-x.
106. Yabuuchi H, Fukuya T, Tajima T et al. Salivary gland tumors: diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. Radiology 2003; 226 (2): 345–354. Doi: 10.1148/radiol.2262011486.
107. Hisatomi M, Asaumi J, Konouchi H et al. Assessment of dynamic MRI of Warthin‘s tumors arising as multiple lesions in the parotid glands. Oral Oncol 2002; 38 (4): 369–372. Doi: 10.1016/s1368-8375 (01) 00073-2.
108. Park J, Inoue S, Ishizuka Y et al. Salivary gland masses: dynamic MR imaging and pathologic correlation. Nippon Igaku Hoshasen Gakkai Zasshi 1997; 57 (9): 581–585.
109. Xiang S, Ren J, Xia Z et al. Histogram analysis of dynamic contrast-enhanced magnetic resonance imaging in the differential diagnosis of parotid tumors. BMC Med Imaging 2021; 21 (1): 194. Doi: 10.1186/s12880-021-00724-y.
110. van Herpen C, Vander Poorten V, Skalova A et al. Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up. ESMO Open 2022; 7 (6): 100602. Doi: 10.1016/j.esmoop.2022.100602.
111. Kong X, Li H, Han Z. The diagnostic role of ultrasonography, computed tomography, magnetic resonance imaging, positron emission tomography/computed tomography, and real-time elastography in the differentiation of benign and malignant salivary gland tumors: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 2019; 128 (4): 431–443.e1. Doi: 10.1016/j.oooo.2019.06.014.
112. Stoia S, Băciuț G, Lenghel M et al. Cross-sectional imaging and cytologic investigations in the preoperative diagnosis of parotid gland tumors – an updated literature review. Bosn J Basic Med Sci 2021; 21 (1): 19–32. Doi: 10.17305/bjbms.2020.5028.
113. Hu YH, Zhang CY, Xia RH et al. Prognostic factors of carcinoma ex pleomorphic adenoma of the salivary glands, with emphasis on the widely invasive carcinoma: a clinicopathologic analysis of 361 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol 2016; 122 (5): 598–608. Doi: 10.1016/j.oooo.2016.06.005.
114. Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 2001; 32 (6): 596–604. Doi: 10.1053/hupa.2001.25000.
115. Zbären P, Zbären S, Caversaccio MD et al. Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg 2008; 138 (5): 601–605. Doi: 10.1016/j.otohns.2008.01.013.
116. Geiger JL, Ismaila N, Beadle B et al. Management of salivary gland malignancy: ASCO guideline. J Clin Oncol 2021; 39 (17): 1909–1941. Doi: 10.1200/JCO.21.00449.
117. Benito DA, Badger C, Hoffman HT et al. Recommended imaging for salivary gland disorders. Curr Otorhinolaryngol Rep 2020; 8 (3): 311–320. Doi: 10.1007/s40136-020-00299-2.
118. Kendi AT, Magliocca KR, Corey A et al. Is there a role for PET/CT parameters to characterize benign, malignant, and metastatic parotid tumors? AJR Am J Roentgenol 2016; 207 : 635–640.
119. Som PM, Brandwein M. Salivary glands. In: Som PM, Curtin HD, editors. Head and neck imaging. 3rd ed. Vol. 2. St. Louis: Mosby-Year Book 1996 : 823–914.
120. Bialek EJ, Jakubowski W, Karpinska G. Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg 2003; 129 (9): 929–933. Doi: 10.1001/archotol.129.9.929.
121. Shimizu M, Ussmuler J, Hartwein J et al. Statistical study for sonographic differential diagnosis of tumorous lesions in the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88 (2): 226–233. Doi: 10.1016/s1079-2104 (99) 70120-4.
122. Zajkowski P, Jakubowski W, Bialek EJ et al. Pleomorphic adenoma and adenolymphoma in ultrasonography. Eur J Ultrasound 2000; 12 (1): 23–29. Doi: 10.1016/s0929-8266 (00) 00096-3.
123. Carotti M, Ciapetti A, Jousse-Joulin S et al. Ultrasonography of the salivary glands: the role of grey-scale and colour/power Doppler. Clin Exp Rheumatol 2014; 32 (1 Suppl 80): S61–S70.
124. Alibek S, Zenk J, Bozzato A et al. The value of dynamic MRI studies in parotid tumors. Acad Radiol 2007; 14 (6): 701–710. Doi: 10.1016/j.acra.2007.03.004.
125. Sharama M, Chintamani, Saxena S et al. Squamous cell carcinoma arising in unilateral Warthin‘s tumor of parotid gland. J Oral Maxillofac Pathol 2008; 12 (2): 82–84. Doi: 10.4103/0973-029X.44585.
126. Howlett DC, Kesse KW, Hughes DV et al. The role of imaging in the evaluation of parotid disease. Clin Radiol 2002; 57 (8): 692–701. Doi: 10.1053/crad.2001.0865.
127. Ikeda M, Motoori K, Hanazawa T et al. Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation. AJNR Am J Neuroradiol 2004; 25 (7): 1256–1262.
128. Holgado A, León X, Llansana A et al. Warthin‘s tumour as a parotid gland incidentaloma identified by PET-CT scan in a large series of cases. Indian J Otolaryngol Head Neck Surg 2024; 76 (4): 3046-3050. Doi: 10.1007/s12070-024-04592-0.
129. Bradley PJ. Adenoid cystic carcinoma evaluation and management: progress with optimism! Curr Opin Otolaryngol Head Neck Surg 2017; 25 (2): 147–153. Doi: 10.1097/MOO.0000 000000000347.
130. Hyravý M, Stárek I, Salzman R et al. Biologické chování adenoidně cystického karcinomu velkých slinných žláz. Otorinolaryngol Foniatr 2020; 69 (4): 151–157.
131. Su HZ, Li ZY, Hong LC et al. Machine learning model for diagnosing salivary gland adenoid cystic carcinoma based on clinical and ultrasound features. Insights Imaging 2025; 16 (1): 96. Doi: 10.1186/s13244-025-01974-y.
132. Wang Y, Guo X, Yu K et al. Adenoid cystic carcinoma of head and neck: summary and review of imaging findings. Heliyon 2023; 9 (11): e21901. Doi: 10.1016/j.heliyon.2023.e21901.
133. Peraza A, Gómez R, Beltran J et al. Mucoepidermoid carcinoma: an update and review of the literature. J Stomatol Oral Maxillofac Surg 2020; 121 (6): 713–720. Doi: 10.1016/j.jormas.2020.06.003.
134. Pires FR, Almeida OP, Araújo VC et al. Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg 2004; 130 (2): 174–180. Doi: 10.1001/archotol.130.2.174.
135. Awwad R, Hsu J et al. Mucoepidermoid carcinoma of the parotid gland: an unusual presentation. Am J Otolaryngol 2006; 27 (5): 344–345. Doi: 10.1016/j.amjoto.2005.11.013.
136. Christe A, Waldherr C, Hallett R et al. MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol 2011; 32 (7): 1202–1207. Doi: 10.3174/ajnr.A2520.
137. Limongelli L, Forte M, Favia G et al. Mucoepidermoid carcinoma of the minor salivary glands diagnosed by high definition ultrasound and fine needle aspiration: a Milan system based retrospective study. Diagnostics (Basel) 2025; 15 (9): 1182. Doi: 10.3390/diagnostics15091182.
138. Gong X, Xiong P, Liu S et al. Ultrasonographic appearances of mucoepidermoid carcinoma of the salivary glands. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114 (3): 382–387. Doi: 10.1016/j.oooo.2012.04.014.
139. Ban X, Hu H, Li Y et al. Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma. Insights Imaging 2022; 13 : 119. Doi: 10.1186/s13244-022-01245-0.
140. Wang C, Yu Q, Li S et al. Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings. Dentomaxillofac Radiol 2021; 50 (7): 20200485. Doi: 10.1259/dmfr.20200485.
141. Ding A, Li J, Gong X et al. Gray scale and Doppler ultrasonography features of the carcinoma ex pleomorphic adenoma. Dentomaxillofac Radiol. 2018; 47 (4): 20170268. Doi: 10.1259/dmfr.20170268.
142. Kato H, Kanematsu M, Mizuta K et al. Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging AJNR Am J Neuroradiol 2008; 29 (5): 865-867. Doi: 10.3174/ajnr.A0974.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)
Article was published inOtorhinolaryngology and Phoniatrics
2026 Issue 2-
All articles in this issue
- Risk of thermal damage during transcanal endoscopic ear surgery
- Relevance of level I neck dissection in oropharyngeal carcinoma
- Simulation of one sided hearing loss – a case report
- OSATS assessment and its use in otorhinolaryngology
- History, present and future of the Department of Otorhinolaryngology and Head and Neck Surgery at the Faculty of Medicine, Palacký University in Olomouc, and the Olomouc University Hospital
- Challenges in the management of metastatic cutaneous squamous cell carcinomas of the head and neck
- Upper airway endoscopy in wakefulness and drug-induced sleep in obstructive sleep apnea
- Preoperative diagnosis of salivary gland tumors
- Core needle biopsy in the diagnosis of parotid gland tumors
- Necrotizing external otitis: literature review and novel management recommended for necrotizing external otitis
- Successful stapedoplasty complicated by a perilymphatic gusher: immediate sealing via piston placement
- Two hundred cochlear implantations at the Department of Otolaryngology and Head and Neck Surgery, University Hospital Hradec Králové
- Prof. Anton Kollár, MD, DrSc, has passed away
- Otorhinolaryngology and Phoniatrics
- Journal archive
- Current issue
- Online only
- About the journal
Most read in this issue- Simulation of one sided hearing loss – a case report
- Relevance of level I neck dissection in oropharyngeal carcinoma
- Risk of thermal damage during transcanal endoscopic ear surgery
- OSATS assessment and its use in otorhinolaryngology
Login#ADS_BOTTOM_SCRIPTS#Forgotten passwordEnter the email address that you registered with. We will send you instructions on how to set a new password.
- Career