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Innate immunity of the middle ear and its role in otitis media


Authors: Hlávková Z. 1;  M. Suchánková 2;  L. Varga 3
Authors‘ workplace: Otorinolaryngologické oddelenie, FN Trnava 1;  Imunologický ústav LF UK v Bratislave 2;  Klinika otorinolaryngológie a chirurgie hlavy a krku LF UK a UN Bratislava 3
Published in: Otorinolaryngol Foniatr, 71, 2022, No. 1, pp. 24-32.
Category: Review Article
doi: https://doi.org/10.48095/ccorl202224

Overview

Otitis media is one of the most common diseases in the world and generally it also belongs to the most frequent causes of hearing loss. In some cases, it may progress to chronic otitis media despite adequate initial treatment. Due to its complex pathogenesis and growing resistance of pathogens to antibio­tic treatment, it is necessary to look for other therapeutic procedures that could be used to modulate and treat this disease. Therefore, it is essential to understand the role of innate immunity of the middle ear in defence against microorganisms. In this article, we discuss the role of innate immunity in otitis media and point to the role of innate immune cells in protecting the middle ear in the light of current knowledge. The innate immune system in the middle ear is responsible for rapid identification and subsequent elimination of pathogens. Cells of the immune system express a multitude of receptors with diverse functions to eliminate many infections before a weakly antigen-sensitized adaptive immunity develops.

Keywords:

immunogenetics – otitis media – middle ear immunity


Sources

1. Schilder AG, Chonmaitree T, Cripps AW et al. Otitis media. Nat Rev Dis Primers 2016; 2: 16063. Doi: 10.1038/nrdp.2016.63.

2. Principi N, Marchisio P, Rosazza C et al. Acute otitis media with spontaneous tympanic membrane perforation. Eur J Clin Microbio­l Infect Dis 2017; 36 (1): 11–18. Doi: 10.1007/ s10096-016-2783-9.

3. Oh JH, Kim WJ. Interaction between allergy and middle ear infection. Curr Allergy Asthma Rep 2016; 16 (9): 66. Doi: 10.1007/s11882-016-0646-1.

4. Robb PJ, Williamson I. Otitis media with effusion. In: Scott-Brown‘s Otorhinolaryngology and Head and Neck Surgery: Volume 2: Paediatrics, The Ear, and Skull Base Surgery. Edited by Watkinson JC, Clarke RW. USA: CRC Press; 2018: 115–135.

5. Jurovčík M, Borský J, Dytrych P et al. První příznaky sekretorické otitidy u novorozenců operovaných pro rozštěpovou vadu – záchyt v desetiletém souboru. Otorinolaryngol Foniatr 2020; 69 (2): 55–61.

6. Bhutta MF, Thornton RB, Kirkham LS et al. Understanding the aetiology and resolution of chronic otitis media from animal and human studies. Dis Model Mech 2017; 10 (11): 1289–1300. Doi: 10.1242/dmm.029983.

7. Browning CG. Condition of middle ear-classification. In: Scott-Brown‘s Otolaryngology. edn. Edited by Kerr AG. London: Arnold 2008: 3396–3401.

8. Vanneste P, Page C. Otitis media with effusion in children: Pathophysiology, dia­gnosis, and treatment. A review. J Otol 2019; 14 (2): 33–39. Doi: 10.1016/j.joto.2019.01.005.

9. Chrobok V, Pellant A, Profant M. Cholesteatom spánkové kosti. Havlíčkův Brod: Tobiáš 2008.

10. McDonald DR, Levy O. Innate immunity. In: Clinical Immunology: Principles and Practice. edn. Edited by Rich RR, Fleisher TA, Shearer WT, Schroeder H, Frew AJ, Weyand CM. The Netherlands: Elsevier 2018.

11. Carrillo JLM, García FPC, Coronado OG et al. Physiology and pathology of innate immune response against pathogens. IntechOpen 2017. Doi: 10.5772/intechopen.70556.

12. Pancer Z, Cooper MD. The evolution of adaptive immunity. Annu Rev Immunol 2006; 24: 497–518. Doi: 10.1146/annurev.immunol.24.021 605.090542.

13. Mansour S, Magnan J, Haidar H et al. Comprehensive and Clinical Anatomy of the Middle Ear. Cham: Springer 2019.

14. Leichtle A, Lai Y, Wollenberg B et al. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep 2011; 11 (1): 78–84. Doi: 10.1007/s11882-010-0158-3.

15. Bartlett JA, Fischer AJ, McCray PBJ. Innate immune functions of the airway epithelium. Contrib Microbio­l 2008; 15: 147–163. Doi: 10.1159/000136349.

16. Mittal R, Kodiyan J, Gerring R et al. Role of innate immunity in the pathogenesis of otitis media. Int J Infect Dis 2014; 29: 259–267. Doi: 10.1016/j.ijid.2014.10.015.

17. Park K, Moon SK, Choung YH et al. Expression of beta-defensins in human middle ear cholesteatoma. Acta Otolaryngol 2003; 123 (2): 236–240. Doi: 10.1080/0036554021000028102.

18. Kuchynková Z, Pácová H. Defensiny – důležitá složka přirozené imunity v obraně proti infekci. Otorinolaryngol Foniatr 2008; 57 (1): 36–39.

19. Mayer G. Immunology – chapter one innate (non-specific) immunity. [online]. Dostupné z: http: //www.microbio­logybook.org/ghaffar/innate-back.htm.

20. Underwood M, Bakaletz L. Innate immunity and the role of defensins in otitis media. Curr Allergy Asthma Rep 2011; 11 (6): 499–507. Doi: 10.1007/s11882-011-0223-6.

21. Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol 2012; 189 (6): 2689-2695. Doi: 10.4049/jimmunol.1201719.

22. Thornton RB, Wiertsema SP, Kirkham LA et al. Neutrophil extracellular traps and bacterial bio­films in middle ear effusion of children with recurrent acute otitis media – a potential treatment target. PLoS One 2013; 8 (2): e53837. Doi: 10.1371/journal.pone.0053837

23. Val S, Poley M, Brown K et al. Proteomic characterization of middle ear fluid confirms neutrophil extracellular traps as a predominant innate immune response in chronic otitis media. PLoS One 2016; 11 (4): e0152865. Doi: 10.1371/journal.pone.0152865.

24. Jacob TM, Indrasingh I, Yadav BK et al. Langerhans cells in the human tympanic membrane in health and disease: a morphometric analysis. Otol Neurotol 2013; 34 (2): 325–330. Doi: 10.1097/MAO.0b013e31826db ce5.

25. Massa HM, Lim DJ, Kurono Y et al. Middle ear and eustachian tube mucosal immunology. Mucosal Immunology 2015: 1923–1942. Doi: 10.1016/B978-0-12-415847-4.00101-4.

26. Paul S, Lal G. The Molecular mechanism of natural killer cells function and its importance in cancer immunotherapy. Front Immunol 2017; 8: 1124. Doi: 10.3389/fimmu.2017.01124.

27. Kumagai Y, Akira S. Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol 2010; 125 (5): 985–992. Doi: 10.1016/j.jaci.2010.01.058.

28. Kurabi A, Pak K, Ryan AF et al. Innate immunity: Orchestrating inflammation and resolution of otitis media. Curr Allergy Asthma Rep 2016; 16 (1): 6. Doi: 10.1007/s11882-015-0585-2.

29. Wigand M, Hoffmann TK, Ryan AF et al. The role of innate immunity in otitis media. HNO 2018; 66 (6): 464–471. Doi: 10.1007/s00106- 018-0501-x.

30. Lee YW, Chung Y, Juhn SK et al. Activation of the transforming growth factor beta pathway in bacterial otitis media. Ann Otol Rhinol Laryngol 2011; 120 (3): 204–213. Doi: 10.1177/000348941112000310.

31. Kawauchi H. Mucosal regulatory system for the balanced immunity in the middle ear and nasopharynx. In: Mucosal Vaccines. Edited by Kiyono H, Pascual DW: Academic Press 2020: 313–323.

32. Martinez I, Oliveros JC, Cuesta I et al. Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front Microbio­l 2017; 8: 276. Doi: 10.3389/fmicb.2017.00276.

33. Cambi A, Koopman M, Figdor CG. How C-type lectins detect pathogens. Cell Microbio­l 2005; 7 (4): 481–488. Doi: 10.1111/j.1462-5822.2005.00506.x.

34. Jung SY, Kim SS, Kim YI et al. Expression, Distribution, and Role of C-Type Lectin Receptors in the Human and Animal Middle Ear and Eustachian Tube: A Review. Molecules 2018; 23 (4). Doi: 10.3390/molecules23040734.

35. Kim SH, Han SH, Byun JY et al. Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma. Acta Otolaryngol 2017; 137 (6): 581–587. Doi: 10.1080/00016489. 2016.1269196.

36. Ford JW, McVicar DW. TREM and TREM- -like receptors in inflammation and disease. Curr Opin Immunol 2009; 21 (1): 38–46. Doi: 10.1016/j.coi.2009.01.009.

37. Cao C, Gu J, Zhang J. Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential bio­marker for the dia­gnosis of infectious diseases. Front Med 2017; 11 (2): 169–177. Doi: 10.1007/s11684-017-0505-z.

38. Nguyen AH, Berim IG, Agrawal DK. Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells. Expert Rev Clin Immunol 2015; 11 (7): 849–857. Doi: 10.1586/1744666X.2015.1043893.

39. Mittal R, Robalino G, Gerring R et al. Immunity genes and susceptibility to otitis media: a comprehensive review. J Genet Genomics 2014; 41 (11): 567–581. Doi: 10.1016/j.jgg.2014. 10.003.

40. Carroll SR, Zald PB, Soler ZM et al. Innate immunity gene single nucleotide polymorphisms and otitis media. Int J Pediatr Otorhinolaryngol 2012; 76 (7): 976–979. Doi: 10.1016/j.ijporl.2012.03.011.

41. Emonts M, Veenhoven RH, Wiertsema SP et al. Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media. Pediatrics 2007; 120 (4): 814–823. Doi: 10.1542/peds.2007-0524.

42. Toivonen L, Vuononvirta J, Mertsola J et al. Polymorphisms of mannose-binding lectin and toll-like receptors 2, 3, 4, 7 and 8 and the risk of respiratory infections and acute otitis media in children. Pediatr Infect Dis J 2017; 36 (5): e114–e122. Doi: 10.1097/INF.0000000000001479.

43. Kaur R, Morris M, Pichichero ME. Epidemiology of acute otitis media in the postpneumococcal conjugate vaccine era. Pediatrics 2017; 140 (3). Doi: 10.1542/peds.2017-0181.

44. Forstová G, Šlapák I. Podíl Haemophilus influenzae b na akutních zánětech středouší a meningitidách otogenního původu u dětí po zavedení očkování antihemofilovou vakcínou. Otorinolaryngol Foniatr 2015; 64 (1): 8–12.

45. Feleszko W, Marengo R, Vieira AS et al. Immunity-targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children. Clin Otolaryngol 2019; 44 (4): 502–510. Doi: 10.1111/coa.13335.

46. Jara-Perez JV, Berber A. Primary prevention of acute respiratory tract infections in children using a bacterial immunostimulant: a double-masked, placebo-controlled clinical trial. Clin Ther 2000; 22 (6): 748–759. Doi: 10.1016/S0149-2918 (00) 90008-0.

47. Gutierrez-Tarango MD, Berber A. Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months. Chest 2001; 119 (6): 1742–1748. Doi: 10.1378/chest.119.6. 1742.

48. Marengo R, Ortega Martell JA, Esposito S. Paediatric Recurrent Ear, Nose and Throat Infections and Complications: Can We Do More? Infect Dis Ther 2020; 9 (2): 275–290. Doi: 10.1007/s40121-020-00289-3.

49. Short KR, von Kockritz-Blickwede M, Langereis JD et al. Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infect Immun 2014; 82 (1): 364–370. Doi: 10.1128/IAI.01104-13.

50. Neff BA, Voss SG, Carlson ML et al. Treatment of eosinophilic otitis media with pegylated interferon-alpha 2a and 2b. Laryngoscope 2017; 127 (5): 1208–1216. Doi: 10.1002/lary.26303.

51. Chao J, Dewyer N, McKenna MJ. Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab. Ann Otol Rhinol Laryngol 2019; 128 (4): 365–368. Doi: 10.1177/0003489418823790.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)

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