Sildenafil for Treatment of Erectile Dysfunction in Men with Chronic Carbon Disulfide Intoxication*
1; A. Orszag
1; J. Vrabec
2; D. Farkašová
Department of Industrial Medicine and Toxicology, School of Medicine Comenius University, Bratislava, Slovakia
Head: Igor Batora, MD, PhD, Associate professor
1; Medical Sexology Institute, Bratislava, Slovakia, Head: Jan Vrabec, MD, PhD, Associate professor
2; Pfizer H. C. P. Slovakia
Pracov. Lék., 57, 2005, No. 2, s. 73-77.
Occurrence of erectile dysfunction (ED) in viscose rayon workers with chronic carbon disulfide (CS₂) intoxication recognized as an occupational disease is well known. The aim of the study was to evaluate the efficacy of sildenafil in patients with ED attributable to chronic CS₂ intoxication. Seventeen men were former rayon workers with ED and chronic CS₂ intoxication recognized as an occupational disease. The sildenafil efficacy was assessed using the responses to questions according to the International Index of Erectile Function (IIEF). A positive response was recorded in all 17 patients. After treatment with sildenafil, a significant score difference was observed in all IIEF questions with the exception of Question 12 (rating of sexual desire). Moreover, the treatment with sildenafil significantly improved the ability to achieve and maintain an erection also in all subgroups of men with ED (age, duration of ED, duration of CS₂ exposure and antidepressant medication). Sildenafil was an effective, reliable, and well-tolerated treatment of erectile dysfunction in men with chronic carbon disulfide intoxication.
sildenafil, erectile dysfunction, carbon disulfide
Hygiene and epidemiology