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proLékaře.cz / Journals / Internal Medicine / 2019 - 2

IL-1 family cytokines in chronic inflammatory disorders

Czech version

Authors: Ilja Stříž
Authors‘ workplace: Pracoviště klinické a transplantační imunologie IKEM, Praha
Published in: Vnitř Lék 2019; 65(2): 81-85
Category:

Overview

IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β a IL-37γ) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects. They are involved not only in defense mechanisms and physiological modulation of homeostatic processes, but also in the imunopathogenesis of many diseases including rheumatoid arthritis, inflammatory bowel disease, autoimmune and auto-inflammatory diseases. Recently, advances in biologic therapy enabled blocking of IL-1α, IL-1β, IL-18, and IL-33 with new monoclonal antibodies, soluble receptors, or recombinant binding proteins.

Keywords:

Cytokines – inflammation – interleukin 1

Sources

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Labels
Diabetology Endocrinology Internal medicine
Defensive and damaging inflammation: basic characteristics
Heterogeneity of lymphocytes as central operating units of the immune system
Microbiota, immunity and immunologically-mediated diseases
Primary immunodeficiencies in adults
Secondary immunodeficiency as a consequence of chronic diseases
Treatment of antibody immunodeficiency
Adverse effects of immunoglobulin therapy
Current trends in immunosuppressive treatment
The role of allergology in internal medicine today and vice versa
Anaphylactic symptoms and anaphylactic shock
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