Vedolizumab – a novel anti-integrin antibody with high gastrointestinal selectivity
Authors:
M. Bortlík
Authors‘ workplace:
Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a. s. a Interní klinika 1. LF UK a ÚVN Praha
Published in:
Gastroent Hepatol 2014; 68(6): 481-484
Category:
IBD: Review Article
doi:
https://doi.org/10.14735/amgh2014481
Overview
Development of new drugs for patients with inflammatory bowel diseases takes into consideration information on mechanisms of inflammatory response in the gut. The concept of antibodies blocking the interaction between leucocyte (integrins) and endothelial cell adhesion molecules (addressins) has resulted in development of vedolizumab, a novel monoclonal antibody against integrin α4β7. Vedolizumab acts selectively in the gut and does not affect immune reactivity within the central nervous system. Clinical trials have confirmed its efficacy for active Crohn’s disease and especially ulcerative colitis.
Key words:
vedolizumab – inflammatory bowel disease – integrin – monoclonal antibody
The author declares he has no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.
Submitted:
17. 11. 2014
Accepted:
8. 12. 2014
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