Endothelial dysfunction and multiorganomultivascular (polyorganopolyvascular) disease


Authors: Peter Gavorník;  Andrej Dukát;  Ľudovít Gašpar;  Martin Čaprnda;  Alena Uhrinová;  Kristína Letková;  Naďa Hučková;  Laura Gužiková;  Katarína Böhmerová;  Peter Sabaka;  Jana Hodulíková;  Gabriela Gubová;  Alexandra Kunová;  Mária Šulanová
Authors‘ workplace: II. interná klinika, Prvé angiologické pracovisko, LF UK a Univerzitná nemocnica Bratislava
Published in: Forum Diab 2012; 1(2-3): 77-85
Category: Topic

Overview

Aim:
The aim of this Document of the Angiologists´ Section of the Slovak Medical Chamber (AS SMC, 2012) is to address a number of studies on endothelial dysfunction, arterial hypertension, metabolic syndrome and type 2 diabetes mellitus published in the last years in order to assess their contribution to our expanding knowledge of the multiorganomultivascular disease.

Discussion:
Angiometabolic syndrome X (AS SMC,1999) has been commonly defined by the presence of ten risk factors (hypersigns): hyperglycaemia (diabetes mellitus); hyperinsulinaemia (insulin resistance); hyperlipoproteinaemia (dyslipidaemia) – Non-Alcoholic Fatty Liver Disease (NAFLD); hyperweight (abdominal obesity) – risk of several cancer types; hypertension (arterial hypertension); hyperuricaemia and/or hyperhomocysteinaemia and/or hyperinflammation – nonvalvular atrial fibrillation; hyperhaemocoagulation (trombophilia); hyperviskosity; hyperactivity sympathetic nervous system and RAAS; hyperandrogenisms and hirsutism; and constitutes one of the most important medical issuess at present. Key etiopatogenetic mechanism of metabolic syndrome has been congenital, primary and secondary endothelial dysfunction that openes and closes the multiple vascular vicious circle (multicirculus vitiosus vasorum). The management of metabolic syndrome X and a significant change in its prevalence and incidence will be of importance in the coming decades in all medical systems of industrialised countries all over the world.

Conclusion:
Angiometabolic syndrome X is cause and consequence of functional (endothelial dysfunction) and of structural vascular injury. Vessels are culprits, implements and victims of arterial hypertension, angiometabolic syndrome X, type 2 diabetes mellitus and of multiorganomultivascular arterial disease.

Key words:
endothelial dysfunction – arterial hypertension – 2 type diabetes mellitus -vessels – multiorganomultivascular arterial disease – circulus vitiosus vasorum


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