Idiopathic Neonatal Hepatitis: Clinical and Pathomorphological Analysis

Czech version

Authors: Roman Hai ¹; Ján Bajaj ¹; Jakub Bízik ²; Filip Babiak ^1,2; Martin Janík ^1,2; Ubomír Straka ^1,2
Authors‘ workplace: Súdnolekárske a patologicko-anatomické pracovisko, Úrad pre dohľad nad zdravotnou starostlivosťou, Martin, Slovenská republika. ¹; Ústav súdneho lekárstva a medicínskych expertíz, Jesseniova lekárska fakulta, Univerzita Komenského v Bratislave, Univerzitná nemocnica Martin, Martin, Slovenská republika. ²
Published in: Soud Lék., 70, 2025, No. 4, p. 34-37
Category: Original Article

Overview

Neonatal hepatitis is a rare but serious liver disease in infants during the first year of life. The term “neonatal hepatitis” refers to infectious liver damage that develops either in utero or during the first three months after birth. The timing of disease onset varies significantly depending on the etiology and is determined by the gestational period during which the fetus was infected as well as the incubation period. Therefore, in some cases, symptoms may appear almost immediately after birth, and in others –⁠ weeks or even months later.

Keywords:

Infants – Neonatal hepatitis – infectious liver damage

Sources

Anochin VA, Gumerova AA. Viral hepatitis in the structure of perinatal infections. Russian Pediatric Journal 2002; 2 : 32–34.
Kaganov BS. Pediatric Hepatology. Moscow: Dinastiya; 2009 : 575.
Orekhov KV. Intrauterine infections. Moscow: Medpraktika-M; 2002 : 252.
Gallegos-Orozco JF, Rakela-Brödner J. Hepatitis viruses: they are not always what they seem. Rev Med Chil 2010; 138(10): 1302–1311.
Korovina NA., Zaplatnikov AL, Cheburkin AV, et al. Cytomegalovirus infection in young children (clinic, diagnosis, current treatment options). A guide for doctors. Moscow: Medpraktika; 2001 : 64.
Yatsik GV, Odinayeva ND, Belyavova IA. Cytomegalovirus infection. Pediatric Practice. Doctor’s Reference 2009; 10 : 5–12.
Lauren N, Kimberlin D, Whitley R. Treatment of congenital cytomegalovirus infection: implications for future therapeutic strategies. J. Antimicrob Chemother 2009; 63(5): 862–867.
Latifa TF, Yeng, Susan M, Eve AR. Mother-tochild transmission of hepatitis C virus. Hepatology 2001; 34 : 223–229.
Leung AK, Sauve RS, Davies HD. Congenital cytomegalovirus infection. J Natl Med Assoc 2003; 95(3): 213–218.
Degtyareva AV, Muchina YuG, Degtyarev DN. Cholestasis syndrome in newborns. A guide for physicians. Moscow: Scientific Center for Obstetrics, Gynecology, and Perinatology V.I. Kulakov, Russian Medical University N.I. Pirogov; 2011 : 36.
Kudashov NI. Cytomegalovirus infection in newborns: diagnosis and treatment. Attending Physician 2006; 3 : 73–78.
Ozhegov AM, Maltsev SV, Myakisheva LS. Clinical-immunological features of active cytomegalovirus and mixed infections in infants. Pediatrics 2001; 2 : 26–31.
Hasosah MY, Kutbi SY, Al-Amri AW, et al. Perinatal cytomegalovirus hepatitis in Saudi infants: a case series. Saudi J Gastroenterol 2012; 18(3): 208–213.

Lombardi G, Garofoli F, Stronati M. Congenital cytomegalovirus infection: treatment, outcomes, and follow-up. J Matern Fetal Neonatal Med 2010, 23(3): 45–48.
Kovalova TA, Chuykova KI, Evtushenko ID, Mukhachova OG. Vertical transmission of hepatitis B and C viruses during pregnancy: prevention options. Gynecology 2011; 13(2): 24–28.
Mayer KP. Hepatitis and its consequences. Moscow: Geotar-Media; 1999 : 432.
Basaraba N. Congenital hepatitis: modern approaches to diagnosis and prevention. Perinatology and Pediatrics 2009; 4 : 79–83.
Seredenin SB. Lectures on Pharmacogenetics. Moscow: MIA; 2004 : 301.
Sopkova D, Farkasova Iannaccone S. Essentials of neonatal autopsy. Folia societatis medicinae legalis Slovacae 2018; 8(1): 16–19.
Vyhnalkova V, Baloghova A, Farkasova Iannaccone S. The latest studies on SIDS. Folia societatis medicinae legalis Slovacae 2011; 1(11): 92–100.

Labels

Anatomical pathology Forensic medical examiner Toxicology

Significant preservation of the heart in human body extremely destroyed by the fire

Odešel MUDr. Petr Lacina

Vzpomínka na soudní lékaře, na které se nezapomíná

Article was published in

Forensic Medicine

2025 Issue 4