Authors: J. Trmal 1; R. Limberková 2 Authors‘ workplace: Krajská hygienická stanice Ústeckého kraje se sídlem v Ústí nad Labem 1; Státní zdravotní ústav Praha 2 Published in: Epidemiol. Mikrobiol. Imunol. 64, 2015, č. 3, s. 139-145 Category: Original Papers
The Czech Republic is a measles free country where only isolated, mostly imported cases have been reported. A measles epidemic that occurred in the Ústí nad Labem Region is presented, with the first case diagnosed early in February 2014 and the last one reported in August 2014. The index case and source of infection to other susceptible patients was an adult male with a history of travel to India. The diagnosis of measles was difficult to make as the patient presented with feverish condition due to co-infection with dengue fever, chikungunya, and measles. The primary measles outbreak occurred in contacts and spread to health workers of the Masaryk Hospital in Ústí nad Labem. The infection further spread to the general population of adults. In total, 305 persons presented with suspected measles. One hundred and eighty-six and of them (61 %) met the criteria for a confirmed case (positive clinical symptoms and laboratory test). Fifty (16.4 %) patients developed typical clinical symptoms and were epidemiologically linked to confirmed cases, but turned out to be antibody negative. In 69 (22.6 %) patients, measles were ruled out. Cases were confirmed by the detection of IgM and IgG antibodies against the measles virus or by RT--PCR. Nearly all cases were verified by the National Reference Laboratory for Rubella, Measles, Mumps, and Parvovirus B 19 of the National Institute of Public Health in Prague. In response to the epidemic, apart from common anti-epidemic measures, emergency vaccination was provided to health professionals of the Masaryk Hospital in Ústí nad Labem. Within two weeks after vaccination, a considerable decline in cases was seen in the vaccinated group. Measles most often occurred in persons born in 1970–1980, but were also observed in the smallest, non-vaccinated children (32 cases). Isolated cases also emerged in duly vaccinated children and adolescents. General recommendations are provided based on practical experience from the epidemic.
Keywords: measles epidemic – health professionals – emergency vaccination – draft measures
1. Špliňo M, Boštíková V. Pokračující epidemie spalniček v EU v roce 2013. Vakcinologie, 2014;8,1 : 43–45.
2. Mustafa M, Veitman S, Vinick M. Subacute measles encephalitis in the immunocompromised host – report of two cases diagnosed by polymerace chain reaction and treated with ribavirin and review of the literature. Clin Infect Dis, 1993;16,5 : 654–660.
3. Arguedas A, Deveikis A, Marks M. Measles. Am J Infect Control, 1981;19,6 : 290–298.
4. Gerte S. Masern keineswegs nur eine harmlose Kinderkrankheit. Therapiewoche, 1992;42,8 : 416–421.
5. Kreth HV. Masern: Järlich 100 Encephalitis. Fille-Ärztl. Prax, 1998;50,5 : 4.
6. Khatib R, Siddigue M, Abrass. Measles associated hepatobiliary disease. Infection, 1993;21,2 : 112–114.
7. Strauss J, Mrázová M, Mačátová I, et al. Ztráta spalničkových mateřských protilátek získaných očkováním proti spalničkám. Česk Epidemiol Mikrobiol Imunol,1991;40,3 : 137 – 143.
8. Shann FA Little bit of measles does you good. Even if measles is eradicated, immunisation may still be desirable in developing countries. BMJ, 1999;319,7201 : 45.
9. Krugman S. Prezent status of measles and rubella immunization in the United States: a medical progress report. J Pediat, 1977;90,1 : 1–12.
10. Albrecht P, Ennis FA, Saltzman EJ, Krugman S. Persistence of maternal antibody in infant beyond 12 months: mechanismus of measles vaccine failure. J Pediatr, 1977;91,5 : 715–718.
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