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Dynamics of the Incidence of Creutzfeldt-Jakob Disease in Slovakia in 1975-2008
Authors: E. Mitrová
Authors‘ workplace: Národné referenčné centrum prionových chorôb, Vedeckovýskumná základňa Slovenskej zdravotníckej univerzity v Bratislave
Published in: Epidemiol. Mikrobiol. Imunol. 58, 2009, č. 4, s. 173-178
Overview
The paper reports on Creutzfeldt-Jakob disease (CJD) occurence in Slovakia in years 1975 - 2008. Changes in the incidence of this most important human prion disease, occurrence of individual forms of the classical CJD variant and the unique, unusually high proportion of genetic CJD are documented. Endo - and exogenous risk factors are analyzed, gaps in the prevention of iatrogenic infection are pointed out and the profylaxis of genetic CJD is discussed.
Key words:
Creutzfeldt-Jakob disease, incidence, risk factors.
Sources
1. Bernoulli, C., Siegfried, J., Baumgartner, G. et al. Danger of accidental person-to person transmission of CJD. Lancet, 1977, 1, 478-479.
2. Collinge, J., Palmer, M., Dryden, A. Genetic predisposition to iatrogenic CJD. Lancet, 1991, 337, 1441-1442.
3. Collins, S., Law, M., Fletcher, A. at al. Surgical treatment and risk of sporadic CJD: a case control study. Lancet, 1999, 353, 693-697.
4. Kovacs, G., Puopulo, A., Ladogana, A. et al. Genetic prion disease: the EUROCJD experience. Hum Gen, 2005, 113, 439-450.
5. Mitrová, E. Some new aspects of CJD epidemiology in Slovakia. Europ J Epidem, 1991, 7, 439-448.
6. Mitrová, E. and Belay, G. Creutzfeldt-Jakob disease with E200K mutation in Slovakia: characterization and development. Acta Virol, 2002, 46, 31-39.
7. Mitrová, E., Mayer,V., Jovankovičová,V. et al. CJD risk and PRNP codon 129 polymorphism: necessity to revalue current data. Europ J Neurol, 2005, 12, 1-4.
8. Swan, K., Baker, A., Brown, L. vCJD patient abnormal prion protein found in a patient with hemophilia at post mortem. www.nationalprionclinic.uk, 17 February 2009.
9. Will, R.G, Ironside, J., Zeidler, M. A new variant of Creutzfeldt-Jakob disease in UK. Lancet,1996, 347, 197-199.
10. WHO manual for strenghtening diagnosis and surveillance of CJD. Geneva, 1998,1-75.
Labels
Hygiene and epidemiology Medical virology Clinical microbiology
Article was published inEpidemiology, Microbiology, Immunology
2009 Issue 4-
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