Authors: A. Hoštacká Authors‘ workplace: Ústav preventívnej a klinickej medicíny, Bratislava Published in: Epidemiol. Mikrobiol. Imunol. , 1999, č. 1, s. 28-30 Category:
The effect of ofloxacin, pefloxacin and tobramycin at subinhibitory concentrations (1/4, 1/8 and 1/16of the MICs) on surface hydrophobicity of the Klebsiella pneumoniae strain was studied. Theantibiotics tested decreased cell surface hydrophobicity in a dose-dependent manner. The mostsignificant reduction of surface hydrophobicity was found after treatment with antibiotics at 1/4 oftheir MICs. Surface hydrophobicity of K. pneumoniae after exposure to these concentrations wasdecreased to 44% (ofloxacin), 50.7% (pefloxacin) and 56.1% (tobramycin) compared with controls.
Key words: Klebsiella pneumoniae – cell surface hydrophobicity – ofloxacin – pefloxacin – tobramy-cin – subinhibitory concentrations.
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