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Methylation pattern in the diagnosis and prognosis of brain cancer


Authors: Aleš Vícha 1,4;  Lucie Štolová 1;  Pavla Jenčová 1;  Michal Zápotocký 1,4;  David Sumerauer 1,4;  Adéla Mišove 1,4;  Miroslav Koblížek 2,4;  Petr Brož 1,3;  Josef Zámečník 2,4;  Martin Kynčl 5;  Petr Libý 6;  Lenka Krsková 2,4
Authors‘ workplace: Klinika dětské hematologie a onkologie 2. LF UK a FN Motol, Praha 1;  Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha 2;  Bioxsys, Ústí nad Labem 3;  Prague Brain Tumour Research Group 4;  Klinika zobrazovacích metod 2. LF UK a FN Motol, Praha 5;  Neurochirurgická klinika dětí a dospělých 2. LF UK a FN Motol, Praha 6
Published in: Čes.-slov. Patol., 57, 2021, No. 3, p. 154-160
Category: Reviews Article

Overview

Examination of changes in the methylation profile of DNA in cancer is currently used to determine the diagnosis or prognostic and predictive biomarkers. It complements histological or molecular biological examinations. At the same time, it helps to identify new diagnostic groups and subgroups. Currently, this diagnosis is most common in brain tumors, where it has become a routine examination. The established methylation profile may help even where the diagnosis or subgroup classification of the disease cannot be determined in any other way, as is the case with medulloblastoma.

Keywords:

Methylation – SNP array – brain tumors – classification


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Czecho-Slovak Pathology

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