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Incidental finding of prostate cancer during surgery for benign prostatic hyperplasia –⁠ how to proceed?


Authors: Peter Polaček;  Otakar Čapoun;  Martin Malý;  Filip Vlček;  Alžběta Kantorová;  Viktor Soukup
Authors‘ workplace: Urologická klinika 1. LF UK a VFN v Praze
Published in: Ces Urol 2025; 29(3): 146-151
Category: Review article
doi: https://doi.org/10.48095/cccu2025021

Overview

The so-called incidental prostate cancer, identified during surgical treatment for benign prostatic hyperplasia, particularly transurethral resection of the prostate, represents a specific clinical scenario with no clearly defined standard of care. This review summarizes current data on the incidence, predictive factors, and options for further diagnosis and treatment of incidental prostate cancer. Special attention is given to the role of postoperative prostate specific antigen levels, multiparametric magnetic resonance imaging, the value of subsequent biopsy, and the prediction of residual cancer presence or absence. The roles of radical prostatectomy and radiotherapy are also discussed, including the risk of urinary incontinence in patients with prior prostate surgery. The aim of this article is to provide a practical overview for urologists and oncologists when making decisions about further management of patients with incidental prostate cancer.

Keywords:

incidental prostate cancer – TUR-P – PSA – radical prostatectomy – radiotherapy


Sources

1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin 2024; 74(1): 12–49. doi: 10.3322/caac.21820.

2. Krejčí D, Mužík J, Šnábl I et al. Portál epidemiologie novotvarů v ČR. [online]. Dostupné z: https: //www.svod.cz.

3. Guo Z, He J, Huang L et al. Prevalence and risk factors of incidental prostate cancer in certain surgeries for benign prostatic hyperplasia: a system-
atic review and meta-analysis. Int Braz J Urol 2022; 48(6): 915–929. doi: 10.1590/S1677-5538.IBJU.2021.0653.

4. Zigeuner RE, Lipsky K, Riedler I et al. Did the rate of incidental prostate cancer change in the era of PSA testing? A retrospective study of 1127 pa-
tients. Urology 2003; 62(3): 451–455. doi: 10.1016/s0090-4295(03)00459-x.

5. Prošvic P, Morávek P, Šimáková E. Incidentální adenokarcinom prostaty u pacientů po radikální cystektomii pro uroteliální karcinom. Ces Urol 2002; 6(1): 37–40. doi: 10.48095/cccu2002009.

6. Šámal V, Richter I, Paldus V et al. Incidence karcinomu prostaty v preparátech po radikální cystoprostatektomii. Histopatologická charakteristika nádorů a posouzení vlivu histologického zpracování preparátu na incidenci nádoru. Ces Urol 2020; 24(1): 42–50. doi: 10.48095/cccu2020001.

7. Polaček P, Kantorová A, Malý M et al. Náhodný nález karcinomu prostaty po výkonu pro benigní hyperplazii prostaty –⁠ jak postupovat? Ces Urol 2024; 28(Suppl. A).

8. Tinmouth WW, Habib E, Kim SC et al. Change in serum prostate specific antigen concentration after holmium laser enucleation of the prostate: a marker for completeness of adenoma resection? J Endourol 2005; 19(5): 550–554. doi: 10.1089/end.2005.19.550.

9. Klein C, Marquette T, Capon G et al. Incidental prostate cancer after holmium laser enucleation of the prostate: incidence and predictive factors for clinical progression. Int J Clin Oncol 2022; 27(6): 1077–1083. doi: 10.1007/s10147-022-02156-2.

10. Ko KJ, Choi S, Song W. The impact of multiparametric magnetic resonance imaging on treatment strategies for incidental prostate cancer after holmium laser enucleation of the prostate. J Clin Med 2023; 12(14): 4826. doi: 10.3390/jcm12144826.

11. Lee LS, Thiruneelakandasivam S, Hong MK et al. Are transrectal prostate biopsies routinely indicated in patients with incidentally diagnosed pros
tate cancer following transurethral resection of the prostate for benign disease? Urol Int 2013; 91(4): 397–403. doi: 10.1159/000350898.

12. Capitanio U, Scattoni V, Freschi M et al. Radical prostatectomy for incidental (stage T1a–T1b) prostate cancer: analysis of predictors for residual dis-
ease and biochemical recurrence. Eur Urol 2008; 54(1): 118–125. doi: 10.1016/j.eururo.2008.02.018.

13. Chung DY, Goh HJ, Koh DH et al. Clinical significance of multiparametric MRI and PSA density as predictors of residual tumor (pT0) following radical prostatectomy for T1a–T1b (incidental) prostate cancer. PLoS One 2018; 13(12): e0210037. doi: 10.1371/journal.pone.0210037.

14. Bokhorst LP, Valdagni R, Rannikko A et al. A decade of active surveillance in the PRIAS study: an update and evaluation of the criteria used to rec-
ommend a switch to active treatment. Eur Urol 2016; 70(6): 954–960. doi: 10.1016/j.eururo.2016.06.007.

15. EAU Guidelines. Edn. presented at the EAU Annual Congress Madrid 2025.

16. Li H, Zhao C, Liu P et al. Radical prostatectomy after previous transurethral resection of the prostate: a systematic review and meta-analysis. Transl Androl Urol 2019; 8(6): 712–727. doi: 10.21037/tau.2019.11.13.

17. Zugor V, Labanaris AP, Porres D et al. Surgical, oncologic, and short-term functional outcomes in patients undergoing robot-assisted prostatectomy after previous transurethral resection of the prostate. J Endourol 2012; 26(5): 515–519. doi: 10.1089/end.2011.0205.

18. Guilhen M, Hennequin C, Ouzaid I et al. Urinary function and quality of life after radiotherapy for prostate cancer in patients with prior history of surgical treatment for benign prostatic hyperplasia. Radiat Oncol 2018; 13(1): 209. doi: 10.1186/s13014-018-1149-0.

19. Liu M, Pickles T, Berthelet E et al. Urinary incontinence in prostate cancer patients treated with external beam radiotherapy. Radiother Oncol 2005; 74(2): 197–201. doi: 10.1016/j.radonc.2004.09.016.

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