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What can be recommended for testicular microlithiasis diagnosis in childhood


Authors: Ivo Novák;  Miloš Bro Ák
Authors‘ workplace: Urologická klinika, Fakultní nemocnice a Lékařská fakulta UK, Hradec Králové
Published in: Ces Urol 2021; 25(1): 40-47
Category: Original Articles

Overview

Novák I, Broďák M. What can be recommended the testicular microlithiasis diagnosis in childhood.

Introduction: Testicular microlithiasis (TM) is a rare disease in the pediatric population. A possible link with testicular tumors (TC) requires appropriate attention to the disease. The paper describes in multiple case reports our personal experiences with this disease.

Materials and Methods: TM were found in 5 patients during screening ultrasound (USG) examination of the testes performed due to other pathologies of the scrotum (hydrocele, testicular retention, varicocele) or positivity in the family history of TC in the years 2010–2020. The age of the patients at the time of diagnosis was 18–155 months (average = 98, median = 126 months). All of them had characteristic bilateral finding. At the same time there were diverse risk factors present in three patients (history of seminoma in the fathers of two patients, one patient after bilateral orchidopexy).

Results: All 5 patients are routinely observed for 12–72 months (average = 50, median = 72 months), perform autopalpation of the testes once a month and undergo USG once a year. In 4 patients there were no changes in the sense of palpation or USG finding that would raise a suspicion of TC. In one patient a small cyst was described on the right testis during one of the control USG at another urology department. During USG at our department a contralateral multiple cystic formation of the epididymis – spermatocele – was found, however a cyst was not found in the right testicle. The usual standard procedure with autopalpation and USG controls followed.

Conclusion: We observed three risk cases of TM with risk factors. Therefore all the patients are monitored not only by autopalpation monthly but also by USG annually. No patient has been indicated for biopsy or orchiectomy yet. For all of them, we expect transfer to subsequent transient care in adulthood.

Keywords:

Testicular microlithiasis – testicular tumors – childhood – ultrasonography


Sources

1. Winter TC, Kim B, Lowrance WT, Middleton WD. Testicular Microlithiasis: What Should You Recommend. Am J Roentgenology 2016; 206(6): 1164–1169.

2. Balawender K, Orkisz S, Wisz P. Testicular microlithiasis: what urologists should know. A review of the current literature. Cent European J Urol 2018; 71(3): 310–314.

3. Goede J, Hack WWM, van der Voort‑Doedens LM, Sijstermans K, Pierik FH. Prevalence of Testicular Microlithiasis in Asymptomatic Males 0 to 19 Years Old. J Urol 2009; 182: 1516–1520.

4. Accardo G, Vallone G, Esposito D, et al. Testicular parenchymal abnormalities in Klinefelter syndrome: a question of cancer? Examination of 40 consecutive patients. Asian J Androl 2015; 17: 154.

5. Cebeci AN, Aslanger A, Ozdemir M. Should patients with Down syndrome be screened for testicular microlithiasis? Eur J Pediatr Surg 2015; 25: 177–180.

6. Heráček J, Sobotka V, Urban M. Mikrolitiáza varlete. Praktický Lékař 2012; 92(3): 157–160.

7. Renshaw AA. Testicular calcifications: Incidence, histology and proposed pathological criteria for testicular microlithiasis. J Urol 1998; 160: 1625–1628.

8. Corut A, Senyigit A, Ugur SA, et al. Mutations in SLC34A2 Cause Pulmonary Alveolar Microlithiasis and Are Possibly Associated with Testicular Microlithiasis. Am J Hum Genet 2006; 79: 650–656.

9. Shanmugasundaram R, Singh J Ch, Kekre NS. Testicular microlithiasis: Is there an agreed protocol? Indian J Urol 2007; 23(3): 234–239.

10. Pedersen MR, Møller H, Rafaelsen SR, et al. Characteristics of symptomatic men with testicular microlithiasis – A Danish cross‑sectional questionnaire study. Andrology 2017; 5: 556–561.

11. Pettersson A, Kaijser M, Richiardi L, et al. Women smoking and testicular cancer: One epidemic causing another? Int J Cancer 2004; 109: 941–944.

12. Mihál V, Zapletalová J, Michálková K. Oboustranná testikulární mikrolitiáza u dítěte s jednostranným kryptorchismem. Pediatr. praxi 2018; 19(1): 51–53.

13. Pedersen MR, Graumann O, Hørlyck A, et al. Inter‑and intraobserver agreement in detection of testicular microlithiasis with ultrasonography. Acta Radiol 2016; 57: 767–772.

14. Pedersen MR, Rafaelsen SR, Møller H, Vedsted P, Osther PJ. Testiculat microlithiasis and testicular cancer: review of the literature. Int Urol Nephrol 2016; 48(7): 1079–1086.

15. Richenberg J, Belfield J, Ramchandani P, et al. Testicular microlithiasis imaging and follow‑up: guidelines of the ESUR scrotal imaging subcommittee. Eur Radiol 2015; 25(2): 323–330.

16. Thomas K, Wood SJ, Thompson AJM, Pilling D, Lewis‑Jones DI. The incidence and significance of testicular microlithiasis in a subfertile population. Br J Radiol 2000; 73(869): 494–497.

17. Aizenstein RI, DiDomenico D, Wilbur AC, O‘Neil HK. Testicular microlithiasis: Association with male infertility. J Clin Ultrasound 1998; 26(4): 195–198.

18. Xu C, Liu M, Zhang FF, et al. The association between testicular microlithiasis and semen parameters in Chinese adult men with fertility intention: Experience of 226 cases. Urology 2014; 84(4): 815–820.

19. de Gouveia Brazao CA, Pierik FH, Oosterhuis JW, et al. Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. J Urol 2004; 171(1): 158–160.

20. von der Maase H, Rørth M, Walbom‑Jørgensen S, et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. Br Med J (Clin Res Ed) 1986; 293(6559): 1398–1401

21. Tan IB, Ang KK, Ching BC, et al. Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults: A meta‑analysis and systematic review. Cancer 2010; 116(19): 4520–4532.

22. DeCastro BJ, Peterson AC, Costabile RA. A 5-Year Followup Study of Asymptomatic Men With Testicular Microlithiasis. J Urol 2008; 179(4): 1420–1423.

23. Wang T, Liu LH, Luo JT, Liu TS, Wei AY. A meta‑analysis of the relationship between testicular microlithiasis and incidence of testicular cancer. Urol J 2015; 12(2): 2057–2064.

24. Patel K V, Navaratne S, Bartlett E, et al. Testicular Microlithiasis: Is Sonographic Surveillance Necessary? Single Centre 14 Year Experience in 442 Patients with Testicular Microlithiasis. Ultraschall der Medizin 2016; 37(1): 68–73.

25. Sharmeen F, Rosenthal MH, Wood MJ, et al. Relationship between the pathologic subtype/initial stage and microliths in testicular germ cell tumors. J Ultrasound Med 2015; 34(11): 1977–1982.

26. Trout AT, Chou J, EcNamara ER, et al. Association between testicular microlithiasis and testicular neoplasia: large multicenter studyin a pediatric population. Radiology 2017; 285 (2): 576–583.

27. Goede J, Hack WWM, Sijstermans K, et al. Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence. Horm Res Paediatr 2011; 76(1): 56–64.

28. Price NR, Charlton A, Simango I, Smith GHH. Testicular microlithiasis: the importance of self examination. J Paediatr Child Health 2014, 50(10): 102–105.

29. Barchetti F, De Marco V, Barchetti G, et al. A Incidental Discovery of Testicular Microlithiasis: What Is the Importance of Ultrasound Surveillance? Two Case Reports. Case Rep Oncol 2013; 6(3): 520–525.

30. Hoei‑Hansen CE, Olesen IA, Jorgensen N, et al. Current approaches for detection of carcinoma in situ testis. Int J Androl 2007; 30(4): 398–404.

Labels
Paediatric urologist Nephrology Urology
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