#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

„Burned-out“ tumour of a testis with metastasis to retroperitoneal lymph node


Authors: Karol Kajo 1;  Michal Kajo 1;  Katarína Macháleková 1;  Július Palaj 2;  Iveta Mečiarová 3;  Peter Zuzák 4;  Emil Tvrdík 5
Authors‘ workplace: Ústav patológie SZU a OÚSA, s. r. o., Bratislava 1;  Klinika onkologickej chirurgie OÚSA, s. r. o., a LF UK, Bratislava 2;  Alpha medical patológia, s. r. o., Bratislava 3;  Interná onkologická klinika OÚSA a TU, Bratislava 4;  sv. VINCENT, s. r. o., Prievidza 5
Published in: Ces Urol 2014; 18(2): 138-143
Category: Case report

Overview

The term “burned-out tumour” refers to a rare clinical entity that represents a complete spontaneous regression of previously untreated testicular cancer with metastases in the retroperitoneum, mediastinum, lymph nodes, lung or liver. We describe the case of a 55-year-old patient with pain in the right lumbar region, in which the CT scan disclosed a tumour mass in the retroperitoneum (sized 70 × 55 × 90 mm), and ultrasonography revealed structural changes in the lower pole of the right testicle. First, the patient underwent a right-sided orchiectomy with histological finding of a scar in the testicle without distinct tumour changes, followed by radical resection of the retroperitoneal tumour, which histology proved to be a metastasis of seminoma in the lymph node. Consequently, the histology in the testis was re-evaluated and determined to be a completely regressed testicular tumour – “burned-out tumour.” Subsequently, patient underwent adjuvant chemotherapy. The pathogenesis of “burned-out” tumours are comprises mainly of immunological factors, ischemia represents another, although less probable cause. Prognosis of “burned-out” tumours in cases of seminomatous germ cell tumours is comparable with those of primary testicular tumours.

Key words:
“burned-out”, regression, seminoma, testis, tumour.


Sources

1. Fabre E, Jira H, Izard V, et al. Burned-out primary testicular cancer. BJU Int 2004; 94(1): 74–78.

2. Balalaa N, Selman M, Hassen W. Burned-out testicular tumor: A case report. Case Rep Oncol 2011; 4: 12–15. doi: 10.1159/000324041.

3. Yucel M, Kabay S, Saracoglu U, et al. Burned-out testis tumour that metastasized to retroperitoneal lymph nodes: a case report. J Med Case Rep 2009, 3: 7266. doi: 10.1186/1752-1947-3-7266.

4. Kar H, Kamer E, Ekinci N, et al. Upper gastrointestinal bleeding as initial presentation of burned-out testicular tumor. Int J Hemat Oncol 2011; 21 (4): 245–248. doi: 10.4999/uhod.09113.

5. Saleh FH, Crotty KA, Hersey P, Menzies SW, Rahman W. Autonomous histopathological regression of primary tumors associated with specific immune responses to cancer antigens. J Pathol 2003; 200: 383–395.

6. Gaytán-Escobar E, Muňoz-Islas E, Colorado-Garcia A, et al. Burned-out testicular tumor with pulmonary and retroperitoneal metastases: a case report. Rev Mex Urol 2010; 70(5): 301–304.

7. Gurioli A, Oderda M, Vigna D, et al. Two cases of retroperitoneal metastasis from a completely regressed burned-out testicular cancer. Urologia 2013; 80(1): 74–79.

8. Scholtz M, Zehender M, Thalmann GN, et al. Extragonadal retroperitoneal germ cell tumor: evidence of origin in the testis. Ann Oncol 2002; 13: 121–124.

9. Bohle A, Studer UE, Sonntag RW, Scheidegger JR. Primary or secondary extragonadal germ-cell tumors? J Urol 1986; 135: 933–943.

10. Kontos S, Doumanis G, Karagianni M, et al. Burned-out testicular tumor with retroperitoneal lymph node metastasis: a case report. J Med Case Rep 2009; 3: 8705. doi: 10.4076/1752-1947-3-8705.

11. Tefany FJ, Barnetson RS, Halliday GM, McCarthy SW, McCarthy WH. Immunocytochemical analysis of the cellular infiltrate in primary regressing and non-regressing malignant melanoma. J Invest Dermatol 1991; 97: 197–202.

12. Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 2006; 30: 858–865.

Labels
Paediatric urologist Nephrology Urology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#