Genitourinary tract infections in patient history do not correlate with prostate cancer biological behaviour and prognosis
Authors:
Jan Hrbáček 1; Michael Urban 1,5; Václav Eis 2; Eva Hamšíková 3; Ruth Tachezy 3; Marek Brabec 4; Jiří Heráček 1,5
Authors‘ workplace:
Urologická klinika 3. LF UK a FNKV, Praha
1; Ústav patologie 3. LF UK a FNKV, Praha
2; Ústav hematologie a krevní transfuze, Praha
3; Ústav informatiky Akademie věd ČR, oddělení nelineárního modelování, Praha
4; Androgeos, Praha
5
Published in:
Ces Urol 2011; 15(3): 172-180
Category:
Original article
Overview
Aim:
An association between genitourinary infection and prostate cancer has not been clearly demonstrated despite the past 20 years research efforts. No research group has investigated, however, the possible role infection could play in prostate cancer behaviour and the disease course.
Material and methods:
In our case-control study, we have evaluated 317 patients who had undergone radical retropubic prostatectomy for a clinically localized prostate cancer; we were looking for a possible correlation between the presence of antibodies (surrogate marker of past infection) to various genitourinary pathogens and the tumour biological behaviour. These sexually transmitted agents were included in the study: human cytomegalovirus, herpes simplex virus 1 and 2, human papillomavirus 6, 11, 16, 18, 31 and 33, Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Neisseria gonorrhoeae and Treponema pallidum.
Results:
We have correlated antibody presence and serum antibody levels with the tumour clinical and pathological characteristics: local staging, Gleason score and prostatic specific antigen level. No clinically significant differences were found.
Conclusion:
No association has been found between prostate cancer biological behaviour – i.e. its prognosis – and genitourinary infectious diseases in patient history.
Key words:
infection, prostatic neoplasms, sexually transmitted diseases, cancer staging.
Sources
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Labels
Paediatric urologist Nephrology UrologyArticle was published in
Czech Urology
2011 Issue 3
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