Advanced methods of external-beam radiation therapy in the treatment of prostate cancer
Authors:
Karel Odrážka- 1 3; Martin Doležel 1,3; Jaroslav Vaňásek 1
Authors‘ workplace:
Oddělení radiační onkologie, Multiscan
s. r. o., Pardubická krajská nemocnice a. s.
Pardubice
1; 1. a 3. lékařská fakulta, Univerzita Karlova
v Praze
2; Katedra radiační onkologie IPVZ, Praha
3
Published in:
Ces Urol 2010; 14(2): 81-91
Category:
Review article
Overview
In the last 20 years, external-beam radiation therapy of prostate cancer made a remarkable progress – entirely new treatment methods emerged and treatment results improved. Treatment planning using computed tomography and calculation of the spatial dose distribution launched the development of conformal techniques of radiation therapy (three-dimensional conformal radiation therapy 3D-CRT,intensity-modulated radiation therapy IMRT). Subsequent progress in imaging technologies and a focus on accurate setup of the radiation beam have opened a period of image-guided radiation therapy (IGRT) that moved conformal methods on higher level of quality and safety. Advanced forms of radiation therapy are associated with better dose distribution in comparison with conventional techniques, resulting in substantial sparing of healthy tissues. Radiation oncology took the advantage of conformal methods in full, aiming at the dose escalation in the prostate area. Randomized studies came to conclusive evidence regarding higher probability of cancer control with supraconventional doses of radiation.
Key words:
prostate cancer, external-beam radiation therapy, conformal techniques, image guidance.
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Paediatric urologist Nephrology UrologyArticle was published in
Czech Urology
2010 Issue 2
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