Authors: M. Důra 1,2; M. Blaško 1; M. Šlajsová 1; J. Štork 1 Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN, Praha, přednosta doc. MUDr. Ondřej Kodet, Ph. D. 1; Bioptická laboratoř s. r. o., Plzeň, vedoucí lékař doc. MUDr. Marián Švajdler Jr., Ph. D 2 Published in: Čes-slov Derm, 101, 2026, No. 2, p. 100-102 Category:
The authors present the case of a 48-year-old woman with multiple lesions of granuloma faciale, one of which was histologically verified. The current perspective on this entity is discussed. The condition is presently regarded as a variant of cutaneous vasculitis. The association between granuloma faciale and IgG4-related disease remains uncertain due to their overlapping features. Lesions of granuloma faciale tend to persist chronically and are typically resistant to therapy.
histopathology – therapy – IgG4-related disease – granuloma faciale
1. BARNADAS, M. A., CURELL, R., ALOMAR, A. Direct immunofluorescence in granuloma faciale: a case report and review of literature. J Cutan Pathol, 2006, 33(7), p. 508–511.
2. BOLOGNIA, J., SCHAFFER, J. V., CERRONI, L. Dermatology. 5th Edition.Philadelphia: Elsevier/Saunders, 2024, 2, p. 433–434.
3. CALONJE, E., BRENN, T., LAZAR, A. J. et al. McKee‘s Pathology of the Skin. 5th Edition. Amsterdam: Elsevier/Saunders, 2019, 2, p. 739–741.
4. CESINARO, A. M., LONARDI, S., FACCHETTI, F. Granuloma faciale: a cutaneous lesion sharing features with IgG4-associated sclerosing diseases. Am J Surg Pathol, 2013, 37(1), p. 66–73.
5. JARDIM, M. M. L., UCHIYAMA, J., KAKIZAKI, P., VALENTE, N. Y. S. Dermoscopy of granuloma faciale: a description of a new finding. An Bras Dermatol, 2018, 93(4), p. 587–589.
6. KAVAND, S., LEHMAN, J. S., GIBSON, L. E. Granuloma faciale and erythema elevatum diutinum in relation to immunoglobulin G4-related disease: an appraisal of 32 cases. Am J Clin Pathol, 2016, 145, p. 401–406.
7. KERL, H., CERRONI, L., KOKOL, R. et al. Diagnostic Cutaneous Pathology: Clinical‐Pathological Correlation of Inflammatory and Other Non‐Neoplastic Skin Diseases, 2 Vols. Graz: Vhj Verlagshaus Jakomini, 2017, p. 1209.
8. LÓPEZ-NAVARRO, N., GALLEGO-DOMINGUEZ, E., VARGAS-NEVADO, A., CASTILLO-MUÑOZ, R., HERRERA, E. Granuloma faciale associated with IgG4-related disease. Clin Exp Dermatol, 2017, 42(7), p. 799–800.
9. ORTONNE, N., WECHSLER, J., BAGOT, M., GROSSHANS, E., CRIBIER, B. Granuloma faciale: a clinicopathologic study of 66 patients. J Am Acad Dermatol, 2005, 53(6), p. 1002–1009.
10. TOKURA, Y. Spectrum of IgG4-related skin disease and differential diagnoses. Hong Kong J Dermatol Venereol, 2020, 28, p. 100–109.
11. WIGLEY, J. E. Eosinophilic Granuloma? Sarcoid of Boeck. Proc R Soc Med, 1945, 38(3), p. 125–126.
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