#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Czech-Slovak Dermatology / 2025 - 4

Hand Eczema Part I: Subtypes, Epidemiology, Diagnosis, Prevention and Treatment

Czech version

Authors: N. Benáková 1;  E. Dastychová 2
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK Praha 1;  Dermatovenerologická klinika u sv. Anny MUNI Brno 2
Published in: Čes-slov Derm, 100, 2025, No. 4, p. 151-168
Category: Reviews (Continuing Medical Education)

Overview

Hand eczema is one of the most common and difficult-to-treat skin conditions in dermatologists’ offices. Regarding the etiopathophysiology, clinical picture and the course, it represents a heterogeneous and variable entity. The treatment should be chosen according to stage and severity, using a stepwise approach, including systemic medication, and always containing emolients. With research and upcoming new groups of drugs, a number of high-quality articles have been published, recently even updated European and German guidelines. For dermatologists, but also allergologists, general practitioners, pediatricians and physicians of other specialities we therefore present an overview of the current situation with commented guidelines for the diagnosis, treatment, prevention and management of hand eczema in the Czech Republic.

Keywords:

Prophylaxis – therapy – : hand eczema – subtypes – management of hand eczema

Sources
  1. AGNER, T., ELSNER, P. Hand eczema: epidemiology, prognosis and prevention. JEADV, 2020, 34, S.1, p. 4–12.
  2. ANTONOV, D., ELSNER, P., SCHLIEMANN. S. Hand dermatitis: a review of clinical features, prevention and treatment. Am J Clin Dermatol, 2015, 16, p. 257–270.
  3. APFELBACHER, CH., AKST, W., MOLIN, S. et al. CARPE: a registry project of the German dermatological Society (DDG) for the characterization and care of chronic hand eczema. JDDG, 2011, 9(9), p. 682–688.
  4. APFELBACHER, CH., BEWLEY, A., MOLIN, S. et al. Prevalence of chronic hand eczema in Europe in adults. Br J Dermatol, 2025, 192(6), p. 1047–1054 doi: 10.1093/bjd/ljaf020.
  5. ARMSTRONG, A., HAHN-PEDERSEN, J., BARTLETT, C. et al. Economic burden of chronic hand eczema: a review. Am J Clin Dermatol, 2022, 23, p. 287 –⁠ 300.
  6. BAUER, A., BRANS, R., BREHLER, R. et al. S2k guideline, diagnosis, prevention and therapy of hand eczema. JDDG, 2023, 21(9), p. 1054–1074.
  7. BENÁKOVÁ, N. Ekzémy a dermatitidy. 4. vyd. Praha: Maxdorf; 2025.280 s. ISBN 978-80-7345-815-7.
  8. BISONETTE, R., AGNER, T., MOLIN, S. et al. Hand eczema. Part 1: epidemiology, pathogenesis, diagnosis and work-up. JAAD, 2024. ahead of print. doi: 10.1016/j.jaad.2024.09.048.
  9. BISSONNETTE, R., AGNER, T., TAYLOR, J. S. et al. Hand Eczema. Part 2: Prevention, management, and treatment, JAAD, 2024. doi: https://doi.org/10.1016/j. jaad.2024.09.049.
  10. BRANS, R., JOHN, S. M. Prognosis of hand eczema. Radiotherapy of hand eczema. In: Textbook of hand eczema. Springer, 2014, p.411–417 a p. 353–359.
  11. CAPUCCI, S., HAHN-PEDERSEN, J., VILSBØLL, A., KRAGH, N. Impact of atopic dermatitis and chronic hand eczema on quality of life compared with other chronic diseases. Dermatitis, 2020, 31, p. 178 –⁠ 184.
  12. COHEN, D. BEWLEY, A.WOLLENBERG, A. et al. Matching-adjusted indirect comparison of the efficacy of delgocitinib and dupilumab in the treatment of moderate to severe atopic hand eczema. Abstract No7996, EADV Congress Amsterdam 2024. Dostupné na www: www.eadv/abstracts_congress_2024/49470.pdf
  13. CORTESI, P. A., SCALONE, L., BELISARI, A. et al. Cost and quality of life in patients with severe chronic hand eczema refractory to standard therapy with topical potent corticosteroids. Contact Dermatitis, 2014, 70(3), p. 158–168.
  14. DASTYCHOVÁ, E., NEČAS, M. Ekzémová onemocnění rukou. Pracov Lék, 2018, 3–4, p. 70–84.
  15. DIEPGEN, T., ELSNER, P., SCHLIEMANN, S. et al. Management von Handekzemen. Leitlinie ICD-10-Ziffer: L20. L23. L24. L25. L30. J Dtsch Dermatol Ges, 2009, 7(S3), p. 1–16.
  16. ELSNER, P., AGNER, T. Hand eczema: treatment. JEADV, 2020, 34 (S1), p. 13–21.
  17. GIMENEZ-ARNAU, A. M., BEWLEY, A., APFELBACHER, C. et al. Physician-reported treatment patterns in chronic hand eczema –⁠ results from the multinational RWEAL medical chart review. Poster prezentovaný na kongresu ESCD v Drážďanech 2024. Dostupné na www: www.dermatologytimes.com (March 5, 2025).
  18. GIMENEZ-ARNAU, A. M. et al. 24-week phase 3 trial comparing the efficacy and safety of topical delgocitinib cream with oral alitretinoin capsules in adults with severe chronic hand eczema. Lancet, 2025, 10, 405, p. 1676–1688.
  19. HAFT, M. A., PARK, H. H., LEE, S. S. et al. Pediatric chronic hand eczema: epidemiology, clinical presentation and management. JAAD Int, 2023, 11, p. 165–173.
  20. HANSEN, A., BRANS, R., SONSMANN, F. Allergic contact dermatitis to rubber accelerators in protective gloves: problems, challenges and solutions. Allergol Select, 2021, 5, p. 335–344.
  21. HEEDE, N. G., THYSSEN, J. P., THUESEN, B. H. et al. Predictive factors of self reported hand eczema in adult Danes: a population based cohort study with 5 year follow-up. Br J Dermatol, 2016, 175(2), p. 287–295.
  22. HO, J.S.S., MOLIN, S. A review of existing and new treatments for the management of hand eczema. J Cut Med Surg, 2023, 25(5), p. 493–503.
  23. CHRISTOFFERS, W. A., POLITIEK, K., COENRAADS, P. J. et al. Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study. JEADV, 2016, 30 (1), p. 63–66.
  24. JAMIL, W., SVENSSON, Å., JOSEFSON, A. et al. Incidence rate of hand eczema in different 34 occupations: A systematic review and meta-analysis. Acta Derm Venereol, 2022,102:adv00681
  25. JUNTONGJIN, P., PONGPRASERT, R. Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema. Dermatol Ther, 2019, 32(4), e12956.
  26. LEFEVRE, M. A., TAUBER, M. Alitretinoin is not suitable treatment for the majority of chronic hand eczema patients. JEADV, 2025, 39, p. 261–262.
  27. POLITIEK, K., VAN DER SCHAFT, J., CHRISTOFFERS, W. A. et al. Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study. JEADV, 2016, 30(8), p.1405 –⁠ 1440.
  28. QUAADE, A.S., SIMONSEN, A.B., HALLING, A.S. et al. Prevalence, incidence, and severity of hand eczema in the general population-a systematic review and meta-analysis. Contact Dermatitis, 2021, 84(6), p. 361–74.
  29. RODUIT, C., FREI, R., DEPNER, M. et al. Phenotypes of atopic dermatitis dependig of the timing of onset. JAMA Pediatr, 2017, 171(7), p. 665–662.
  30. RÖNSCH, H., SCHIFFERS, F., OFENLOCH, R. et al. Chronic hand eczema in Europe: Patient experiences and perspectives (CHEPEP) in qualitative interviews. JEADV, 2023, 37, p. 1306–1405.
  31. RUZICKA, T., LYNDE, C.W., JEMEC, G.B. et al. Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol, 2008,158(4), p. 808–817.
  32. SILVERBERG, J. I., HOU, A., WARSHAW, E. M. et al. Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001–2016. Contact Dermatitis, 2021, 85, p. 46–57.
  33. SILVERBERG, J.I., SIMPSON, B., ABUABARA, K. et al. Prevalence and burden of atopic dermatitis involving the head, neck, face, and hand: a cross sectional study from the TARGET-DERM AD cohort. JAAD, 2023, 89, p. 519–528.
  34. THYSSEN, J. P., SCHUTTELAAR, M. L. A., ALFONSO, J. H. et al. Guidelines for diagnosis, prevention and treatment of hand eczema. Contact Dermatitis, 2022, 86, p. 357–378.
  35. VOCILKOVÁ, A. Kontaktní dermatitida. Čs. Derm, 2005, 80(5), p. 252–260.
  36. VOORBERG, A. N., LOMAN, L., SCHUTTELAAR, M. L. A. Prevalence and severity of hand eczema in the Dutch general population: a cross-sectional, questionnaire study within the lifelines cohort study. Acta Derm Venereol, 2022, 102, adv00626. doi. org/10.2340/actadv.v101.432.
  37. WEIDINGER, S., NOVAK, N. Hand eczema. Lancet, 2024, 404, p. 2476–2486.
  38. WEISSHAAR, E. Chronic hand eczema. Am J Clin Dermatol, 2024, 25, p. 909–926.
  39. YEUNG, K. C. Y., LOWE, J., MOLIN, S. et al. Patterns of pediatric chronic hand eczema: a systematic review with focus on causes and management. J Cut Med Surg, 2025, 29(4), p. 386–393. doi. org/10.1177/12034754251322883.
  40. YNGVESON, M., SVENSSON, A., JOHANISSON, A. et al. Hand dermatosis in upper secondary school pupils. Br J Dermatol, 2000,142(3), p. 485–489.

Poděkování všem recenzentům za přínos k celkové kvalitě článku.

Střet zájmů

N. B. se účastnila Advisory Boardu pro firmu Leo Pharma.
E. D. nespolupracovala s žádnou farmaceutickou firmou.

Do redakce došlo dne 22. 4. 2025.

Adresa pro korespondenci:
MUDr. Nina Benáková, Ph.D.
Dermatovenerologická klinika 1. LF UK Praha
U Nemocnice 2
128 00 Praha 2
e-mail: nina.benakova@email.cz

Labels
Dermatology & STDs Paediatric dermatology & STDs
VEXAS Syndrome: an Adult-Onset Autoinflammatory Disease with Cutaneous Manifestations. A Review
Generalizované folikulárně vázané papuly
Article was published in

Czech-Slovak Dermatology

Issue 4
2025 Issue 4
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#