Autoinflammatory Syndromes with Skin Manifestations
Authors:
P. Cetkovská 1; N. Benáková 2
Authors‘ workplace:
Dermatovenerologická klinika FN a LF UK v Plzni, přednosta prof. MUDr. Karel Pizinger, CSc.
1; Dermatovenerologická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. Jiří Štork, CSc.
2
Published in:
Čes-slov Derm, 90, 2015, No. 4, p. 144-155
Category:
Reviews (Continuing Medical Education)
Overview
The autoinflammatory syndromes represent a newly classified heterogenous subset of familiar or sporadic diseases, that are characterized by seemingly unprovoked episodes of inflammation due to excessive interleukin-1β activation. They manifest mainly in childhood with skin lesions, recurrent attacks of fever and joint symptoms. Their immunopathogenic mechanisms are gradually being revealed due to increasing level of knowledge and it appears that even common dermatoses might have present autoinflammatory signs. Recognition of the pathogenetic role of inflammasomes and key mediators of innate immune system opens the possibility for new targeted therapies.
Key words:
autoinflammatory syndromes – inflammasome – interleukin 1 – periodic fevers – anti IL-1 biologics
Sources
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Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2015 Issue 4
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