Authors: Z. Szép; T. Danilla Authors‘ workplace: Detská kožná klinika LFUK a DFNsP, Bratislavaprednosta doc. MUDr. T. Danilla, PhD. Published in: Čes-slov Derm, , 2004, No. 4, p. 148-154 Category:
Etiopathogenesis of atopic dermatitis is complex. Recent research emphasize the significance ofIgE-mediated autoimmune reactions in the pathogenesis of severe, chronic forms of atopic dermatitis.Group of IgE autoantigens, represented by intracellular proteins playing a role in importantphysiological functions of various cell types, was discovered. They induce formation of IgE autoantibodies,which are the main effectors of autoimmune reaction via mechanism of facilitated antigenpresentation. Autoreactivity is based on the cross-reactivity between exogenous allergens andautoantigens. The review summarizes the role of autoimmunity in the pathogenesis of atopicdermatitis.
Key words: atopic dermatitis - review - IgE mediated autoimmunity
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