Influence of a Keratolytic Pretreatment on the Efficacy and Safety of Tacalcitol in Psoriatic Patients

Czech version

Authors: F. Vosmík; K. Tvrdoňová
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN v Praze, přednosta prof. MUDr. František Vosmík, DrSc.
Published in: Čes-slov Derm, , 2002, No. 2, p. 65-70
Category:

Overview

The efficacy, Safety and tolerability of tacalcitol ointment (Curatoderm©) with and without salicylic acid pretreatment were studied in a single-centre, randomized, intraindividual right-left comparison.Patients with stable psoriasis vulgaris were randomized to pretreatment with salicylic acid on the right (S patients) or left (7 patients) side. After a 2-week pretreatment period, in which 5% salicylic acid in white petrolatum was applied once daily ohly to the test areas randomized to pretreatment, tacalcitol ointment (4 I~g/g) was applied once daily to test areas on both sides of the body for eight weeks or to complete clearing. This was followed by a 4-week follow up period. The reduction in the sum score for erythema, infiltration and scaling at the end of the tacalcitol treatment period was highly significant (p

Key words:
psoriasis - salicylic acid - pretreatment - tacalcitol - Curatoderm©

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Article was published in

Czech-Slovak Dermatology

2002 Issue 2