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proLékaře.cz / Journals / Czech Rheumatology / 2021 - 3

The role of calprotectin in the pathogenesis of rheumatoid arthritis and its use as a biomarker

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Authors: N. Petrovská;  M. Filková
Authors‘ workplace: Revmatologická klinika 1. LF UK, Praha ;  Revmatologický ústav Praha
Published in: Čes. Revmatol., 29, 2021, No. 3, p. 144-149.
Category: Review Article

Overview

Rheumatoid arthritis is a chronic inflammatory autoimmune disease typically affecting the synovial membrane, leading to pannus formation due to interaction among stromal and inflammatory cells and angiogenesis. Calprotectin is an S100A8/S100A9 heterodimer produced by activated neutrophils, monocytes, and macrophages in inflammatory tissue and circulation. In patients with RA, it is mainly produced locally in affected joints promoting inflammation, cartilage destruction, and bone resorption. Calprotectin can be detected in the circulation and used as a soluble biomarker. It appears to be a better marker of disease activity than typically used acute phase reactants; moreover, it can be used as a predictive marker of radiographic progression, therapeutic response, and disease flare.

Keywords:

disease activity – Pathogenesis – rheumatoid arthritis – calprotectin – biomarker

Sources
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Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
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Ošetřovatelský manuál pro perioperační péči pacienta se zánětlivými revmatickými nemocemi
Calcium PyroPhosphate Deposition disease
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2021 Issue 3
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