Current possibilities in the prevention and therapy of ovarian hyperstimulation syndrome

Authors: Hubka P. 1,2;  Višňová H. 2;  Sehnal B. 1;  Lincová M. 1;  Zikán M. 1
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha 1;  IVF Cube SE, Praha 2
Published in: Ceska Gynekol 2021; 86(2): 124-127
doi: 10.48095/cccg2021124


Objective: To present current possibilities of the prevention and therapy of ovarian hyperstimulation syndrome (OHSS). Methods: Literature and guidelines were researched. Results: From the view of safety and prevention of OHSS, antagonistic protocol is suitable. Patients with syndrome of polycystic ovaries benefit from the use of metformin or letrozole that can be sufficient to induce ovulation. As a treatment of imminent OHSS, it is recommended to administer 0.5 mg of cabergoline per os daily as well as low molecular weight heparin subcutaneously in prophylactic dose and to maintain sufficient fluid intake. Diuretics are strongly discouraged to use. To maintain intravascular volume, drained ascites can be reintroduced. Conclusion: We present a review of current literature and recommendations.


assisted reproduction – In vitro fertilization – ovarian hyperstimulation syndrome – prevention – therapy


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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