Clinical and Biological Markers of Persistent Form of Hyperkinetic Disorder (ADHD)
Authors:
I. Drtílková; P. Theiner
Authors‘ workplace:
Psychiatrická klinika LF MU a FN, Brno
přednostka prof. MUDr. E. Češková, CS.
Published in:
Čes. a slov. Psychiat., 104, 2008, No. 4, pp. 167-171.
Category:
Comprehensive Reports
Overview
According to current literature data , based primarily on the DSM IV classification system, persistence of symptomatology of hyperkinetic disorder/ADHD to adulthood occurs in approximately 40-60% of cases, which means that its prevalence in adult population is about 3-5%. According to longitudinal studies the persistent form is often accompanied by incidence of comorbid conduct disorders, oppositional defiant disorder, anxiety and mood disorders and also by adverse living conditions and a positive family history of ADHD. The family studies of adults with ADHD show that the risk of ADHD emergence is higher in children of parents with ADHD in adulthood than in children of parents with ADHD exclusively in childhood. Different features of the remittent and persistent ADHDs are investigated chiefly in molecular-genetic studies and in brain imaging studies.
Key words:
ADHD, children, adolescents, remittent form, persistent form, genetic.
Sources
1. American psychiatric association (APA). Diagnostic and Statistic Manual of Mental Disorders, 4rd Edition (DSM-IV). Washington, DC: American Psychiatric Association, 1994.
2. Barkley, R. A., Fischer, M., Fletcher, K., & Smallish, L.: Persistence of attention deficit hyperactivity disorder into adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology, 111, 2002, pp. 279-289.
3. Biederman, J, Faraone, S. V.: Attention-deficit hyperactivity disorder. Lancet, 366 (9481), 2005, pp. 237-248.
4. Biederman, J.: Attention-deficit/hyperactivity disorder: a selective overview.Biol. Psychiatry, 57, 2005, 11, pp. 1215-1220.
5. Biederman, J., Faraone, S. V., Milberger, S. et al.: Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. J. Am. Acad. Child Adolesc. Psychiatry, 35, 1996, 3, pp. 343-351.
6. Drtílková, I., Šerý, O. et al.: Hyperkinetická porucha. Galén, 2007, 266 s.,ISBN 978-80-7262-419-5.
7. Castellanos, F. X., Lee, P. P., Sharp, W. et al.: Developmental trajectories of brain volume abnormalities in children and adolescents with ADHD. JAMA, 288, 2002, pp. 1740-1748.
8. El-Faddah, M., Laucht, M., Maras, A.: Assotiation of dopamine D4 receptor(DRD4) gene with ADHD in a high risk community sample: a longitudinal study from birth to 11 years of age. J. Neural. Transm,. 111, 2004, 7, pp. 883-889.
9. Faraóne, s. v., perlis, r. h., doyle, a. e. et al.: Molecular genetics of attention-deficit/hyperaktivity disorder. Biol. Psychiatry, 57, 2005, pp. 1313-1323.
10. Halperin, J., Kurt, S. et al.: Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychol. Bull., 132, 2006, 4, pp. 560-581
11. Li, J., Kang, C., Zhang, H., Wang, Y., Zhou, R., Wang, B., Guan, L., Yang, L., Faraóne, S. V.: Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder. Am. J. Med. Genet. Part B, 144B, 2007, pp. 430-433.
12. Mezinárodní klasifikace nemocí. 10. revize. Duševní poruchy a poruchy chování. Diagnostická kriteria pro výzkum. Praha, Psychiatrické centrum, 1996, 179 s.
13. Shaw, P., Eckstrand, K., Sharp,W. et al.: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Biological Sciences/psychology PNAS, 104, 2007, 49, pp. 19649-19654.
14. Schulz, K. P., Newcorn, J. H. et al.: Brain activation gradients in ventrolateral prefronat cortex related to persistence of ADHD in adolescent boys. J. Am. Acad. Child. Adolesc. Psychiatry, 44, 2005, 1, pp. 47-52.
15. Spenser, T. J., Biederman, J., Faraóne, S. V.: Impact of tic disorder on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD. Am. J. Psychiatry, 158, 2001, 4, pp. 611-616.
16. Šerý, O., Drtílková, I., Theiner, P. et al.: Polymorphism of DRD2 gene and ADHD. Neuroendocrinology Letters, 27, 2006, 1, pp. 236-240.
17. Štaif, R., Drtílková, I., Theiner, P. et al.: Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes. Archives of Medical Science, 2, 2006, 4, pp. 235-239.
18. Theiner, P., Drtílková, I., Štaif, R., Šerý, O., Uhrová, A.: Kognitivní funkce jako endofenotypy ADHD v dětském věku. Psychiatrie, 10, 2006, Suppl. 1, s. 74.
19. Wilens, t. e., dodson, w. A.: Clinical perspective of attention-deficit/hyperactivity disorder into adulthood. J. Clin. Psychiatry, 65, 2004, 10, pp. 1301-1313.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2008 Issue 4
Most read in this issue
- ADHD – Symptoms and Gender
- Clinical and Biological Markers of Persistent Form of Hyperkinetic Disorder (ADHD)
- Influencing Cognitive Deficit in Schizophrenia by Repetitive Transcranial Magnetic Stimulation
- ArginMax in the Treatment of Female Sexual Dysfunction