Authors: E. Kitzlerová; O. Kittnar 1; I. Paclt; J. Slavíček 1; M. Anders; A. Dohnalová 1 Authors‘ workplace: Psychiatrická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Raboch, DrSc. Fyziologický ústav 1. LF UK, Praha Published in: Čes. a slov. Psychiat., , 2004, No. 8, pp. 472-480. Category:
The cardio-toxic effects of therapeutic plasma levels of TCA (150 – 200 ng/ml in serum) are notquite so evident. New information about it bring the device of Cardiag 112.2, which can measuresimultaneously the ECG (electrocardiography), VCG (vectorcardiography) and BSPM (method ofbody surface potential mapping). With this device we made 2 studies.In the fi rst one, we tried to prove if in depressive patients in remission, treated with prophylacticdoses of dosulepine, are some statistically signifi cant changes in ECG parameters in dependence withdosulepine plasma levels. 4 electrocardiological parameters were proven to correlate signifi cantlywith dosulepine plasma levels: QRS axis deviation in frontal plane (by the method of VCG) (p
Key words: dosulepine, cardiotoxicity, body potential surface mapping, plasma levels.
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