Authors: I. Dóci; L. Hosák 1; M. Kovářová 2 Authors‘ workplace: Psychiatrická klinika Lekárskej fakulty UPJŠ a FNsP, Košice Psychiatrická klinika Lékařské fakulty UK a FN, Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc. Ústav sociálneho lekárstva Lekárskej fakulty UPJŠ, Košice 2 Published in: Čes. a slov. Psychiat., , 2003, No. 6, pp. 331-336. Category:
Up to a half of the multiple sclerosis patients also suffer from depression. The risk of a suicidalbehavior in these subjects is increased as compared with „non-organic“ depression. At the sametime, depression further deteriorates the patients’ quality of life and his/her disability in additionto the primary neurological disorder. In the presented article, we describe a case of a thirty-yearsoldwoman who has suffered from multiple sclerosis for seven years, and a commorbid depressionhas been present for five years. The treatment with paroxetine proved unsuccessful. Passivity andresignation of the patient represent a barrier from a further therapeutic effort. In the discussionsection, we consider etiology of the depicted depressive symptoms especially as for the treatmentwith interferon beta-1b. The literary knowledge rather testifies against a causal relationshipbetween the administration application of an immunomodulatory agent and an occurance ofa mood disorder in multiple sclerosis. We mention other therapeutic possibilities at the end of thepaper.
Key words: multiple sclerosis, depression, treatment, interferon.
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