Authors: J. Švarc Authors‘ workplace: Psychiatrická klinika FN, Brno, přednostka prof. MUDr. E. Češková, CSc. Published in: Čes. a slov. Psychiat., , 2001, No. 7, pp. 356-363. Category:
The citalopram challenge test (CCT) is a new neuroendocrinological test which shows serotoner-gic activity via prolactin and cortisol plasma levels. Advantages of the CCT comparing to thefenfluramine challenge test are: parenteral i.v. - administration - high citalopram selectivity andsafety. The aim of the study was to elaborate the methodology of CCT, to gather groups of 1)depressive patients, 2) anxious patients and 3) healthy volunteers; and to check the hypothesisabout flattening of the hormonal peak in the group of depressive patients and excessive hormonalpeak in the group of anxious patients, and the hypothesis about the normalization of such modifi-ed responses after antidepressant treatment. The methodology of CCT, observed parameters,obtained data and results are presented: final statistical processing of 3 groups (n = 3x10) showsa constant serotonin response 30-40 minutes after rapid citalopram infusion. PRL response wassignificantly flattened in the group of depressive patients (p
Key words: citalopram, challenge test, depression, anxiety disorder, prolactin, cortisol.
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
