Authors: Marta Kučerová Authors‘ workplace: Univerzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické chemie, a farmaceutické analýzy, Hradec Králové Published in: Čes. slov. Farm., 2025; 74, 1-6 doi: https://doi.org/10.36290/csf.2025.001
Covalent drugs are substances capable of forming a reversible or an irreversible covalent bond with a macromolecular target in the body. Despite the risk of adverse reactions in the organism, the design of such agents has become a trend over the last two decades. Drugs acting by covalent mechanisms from different indication groups are summarized in this article and possibly supported with a reference to the crystallographic structure in the Protein Data Bank. The advantages and the disadvantages of using covalent drugs are also discussed.
covalent bond – targeted covalent inhibitors
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