#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Oral films as perspective dosage form


Authors: Veronika Walicová;  Jan Gajdziok
Authors‘ workplace: Veterinární a farmaceutická univerzita v Brně ;  Ústav technologie léků, Farmaceutická fakulta
Published in: Čes. slov. Farm., 2016; 65, 15-21
Category: Review Articles

Overview

Oral films, namely buccal mucoadhesive films and orodispersible films represent innovative formulations for administration of a wide range of drugs. Oral films show many advantageous properties and are intended for systemic drug delivery or for local treatment of the oral mucosa. In both cases, the film represents a thin layer, which could be intended to adhere to the oral mucosa by means of mucoadhesion; or to rapid dissolution and subsequent swallowing without the need of liquid intake, in the case of orodispersible films. Main constitutive excipients are film-forming polymers, which must in the case of mucoadhesive forms remain on the mucosa within the required time interval. Oral films are currently available on the pharmaceutical market and could compete with conventional oral dosage forms in the future.

Key words:
oral cavity oral filmsbuccal mucoadhesive filmsorodispersible filmsfilm-forming polymers


Sources

1. Dylevský I. Funkční anatomie. Praha: Grada Publishing 2009.

2. Gittings S., Turnbull N., Roberts C. J., Gershkovich P.  Dissolution methodology for taste masked oral dosage forms. J. Control. Release 2014; 173, 32–42.

3. Salamat-Miller N., Chittchang M., Johnston T. P. The use of mucoadhesive polymers in buccal drug delivery. Adv. Drug. Deliv. Rev. 2005; 57, 1666–1691.

4. Sudhakar Y., Kuotsu K., Bandyopadhyay A. K. Buccal bioadhesive drug delivery – a promising option for orally less efficient drugs. J. Control. Release 2006; 114, 15–40.

5. Patel V. F., Liu F., Brown M. B. Advances in oral transmucosal drug delivery. J. Control. Release 2011; 153, 106–116.

6. Preis M., Woertz C., Kleinebudde P., Breitkreutz J. Oromucosal film preparations: classification and characterization methods. Expert Opin. Drug. Deliv. 2013; 10, 1303–1317.

7. Hearnden V., Sankar V., Hull K., Juras D. V., Greenberg M., Kerr A. R., Lockhart P. B., Patton L. L., Porter S., Thornhill M. H. New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv. Drug. Deliv. Rev. 2012; 64, 16–28.

8. Adrian C. L., Olin H. B., Dalhoff K., Jacobsen J. In vivo human buccal permeability of nicotine. Int. J. Pharm. 2006; 311, 196–202.

9. Diaz del Consuelo I., Falson F., Guy R. H., Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J. Control. Release 2007; 122, 135–140.

10. Utoguchi N., Watanabe Y., Suzuki T., Maehara J., Matsumoto Y., Matsumoto M. Carrier-mediated transport of monocarboxylic acids in primary cultured epithelial cells from rabbit oral mucosa. Pharm. Res. 1997; 14, 320–324.

11. Paderni C., Compilato D., Giannola L. I., Campisi G. Oral local drug delivery and new perspectives in oral drug formulation. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2012; 114, 25–34.

12. Ministerstvo zdravotnictví ČR. Český lékopis 2009 – Doplněk 2013. Praha: Grada Publishing 2013.

13. Smart J. D. The basics and underlying mechanisms of mucoadhesion. Adv. Drug Deliv. Rev. 2005; 57, 1556–1568.

14. Lam J. K., Xu Y., Worsley A., Wong I. C. Oral transmucosal drug delivery for paediatric use. Adv. Drug Deliv. Rev. 2014; 73, 50–62.

15. Landová H., Daněk Z., Gajdziok J., Vetchý D., Štembírek J. Mucoadhesive films as perspective oral dosage form. Čes. slov. Farm. 2013; 62, 4–11.

16. Siddiqui M. D. N., Garg G., Sharma P. K. A short review on „A novel approach in oral fast dissolving drug delivery system and their patents“. Adv. Biol. Res. 2011; 5, 291–303.

17. Gajdziok J., Rabišková M. Orálně dispergovatelné lékové formy a technologie jejich výroby. Čes. slov. Farm. 2010; 59, 251–255.

18. Rak J., Král V. Quo vadis pharma industry? Klin. Farmakol. Farm. 2014; 28, 5–7.

19. Dostálek M. Farmakokinetika. Praha: Grada Publishing 2006.

20. Dixit R. P., Puthli S. P. Oral strip technology: overview and future potential. J. Control. Release 2009; 139, 94–107.

21. Seberová E. Orálně dispergovatelná tableta – nová forma desloratadinu na našem trhu. Remedia 2011; 1, 84–87.

22. BioDelivery Sciences International, Inc. BEMA

® technology. http://www.bdsi.com/BEMA_Technology.aspx (13. 1. 2016).

23. SÚKL. Databáze léků. http://www.sukl.cz/modules/medication/ search.php (13. 1. 2016).

24. Vetchý D., Landová H., Gajdziok J., Doležel P., Daněk Z., Štembírek J. Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis. Eur. J. Pharm. Biopharm. 2014; 86, 498–506.

25. FDA Structured Product Labeling. Dosage Forms. http://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162038.htm (13. 1. 2016).

26. Hoffmann E. M., Breitenbach A., Breitkreutz J. Advances in orodispersible films for drug delivery. Expert Opin. Drug Deliv. 2011; 8, 299–316.

27. Murata Y., Isobe T., Kofuji K., Nishida N., Kamaguchi R. Preparation of fast dissolving films for oral dosage from natural polysacharides. Materials 2010; 3, 4291–4299.

28. Batchelor H. K., Fotaki N., Klein S. Paediatric oral biopharmaceutics: key considerations and current challenges. Adv. Drug. Deliv. Rev. 2014; 73, 102–126.

29. Preis M., Knop K., Breitkreutz J. Mechanical strength test for orodispersible and buccal films. Int. J. Pharm. 2014; 461, 22–29.

30. Ghodake P. P., Karande K. M., Osmani R. A., Bhosale R. R., Harkare B. R., Kale B. B. Mouth dissolving films: Innovative vehicle for oral drug delivery. Int. J. Pharma Res. Rev. 2013; 2, 41–47.

31. Breitkreutz J., Boos J. Paediatric and geriatric drug delivery. Expert Opin. Drug Deliv. 2007; 4, 37–45.

32. Wening K., Breitkreutz J. Oral drug delivery in personalized medicine: unmet needs and novel approaches. Int. J. Pharm. 2011; 404, 1–9.

33. Nagar P., Chauhan I., Yasir M. Insights into polymers: film formers in mouth dissolving films. Drug Invent. Today 2011; 3, 280–289.

34. Gajdziok J., Vetchý D. Mukoadhezivní polymery v lékových formách. Chem. Listy 2012; 106, 632–638.

35. Bajerová M., Gajdziok J., Dvořáčková K., Masteiková R., Kollár P. Polosyntetické deriváty celulosy jako základ hydrofilních gelových systémů. Čes. slov. Farm. 2008; 57, 63–69.

36. Okáčová L., Vetchý D., Franc A., Rabišková M., Kratochvíl B. Zvýšení biodostupnosti těžce rozpustných léčivých látek jejich modifikací. Chem. Listy 2010; 104, 21–26.

37. Gilhotra R. M., Ikram M., Srivastava S., Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. J. Biomed. Res. 2014; 28, 81–97.

38. Cui F., He C., He M., Tang C., Yin L., Qian F., Yin C. Preparation and evaluation of chitosan-ethylenediaminetetraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin. J. Biomed. Mater. Res. 2009; 89, 1063–1071.

39. Tesa Labtec GmbH. Fucus on transdermal systems and oral dissolvable films. http://www.tesa-labtec.com/eng (13. 1. 2016).

40. MonoSol Rx®. PharmFilm Technology. http://www.monosolrx. com/ (13. 1. 2016).

41. ODF Technologies Inc. The Oral Dissolving Film Strip Company. http://www.odftechnologies.com/ (13. 1. 2016).

42. NiQuitin®. Niquitin strips. http://www.niquitin.co.uk/products/ niquitin-strips/ (13. 1. 2016).

43. Norgine. Products. http://www.norgine.com/products (13. 1. 2016).

44. Tesa Labtec GmbH. The approval of Zolmitriptan ODF. http://www.tesa-labtec.com/eng/company/press/apr-and-labtec-announce-approval-in-europe-of-zolmitriptan-rapidfilm,3097354,1.html (13. 1. 2016).

Labels
Pharmacy Clinical pharmacology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#