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Where does the development of new antituberculotics aim at?


Authors: Karel Waisser
Published in: Čes. slov. Farm., 2012; 61, 150-158
Category: Review Articles

Došlo 24. května 2012 / Přijato 11. července 2012

Overview

Several research teams in the Czech and Slovak Republics are oriented on the development of new antitubeculotics. The present article is based mainly on the information from the Chemical Abstracts from the year 2011 and the beginning of the year 2012. It is a selection from almost three thousand reports aiming to help our scientists. The article presents topical information which may be of interest to several pharmaceutical professions.

Keywords:
Mycobacterium tuberculosis, antituberculotics, multiresistant mycobacteria, QSAR, evaluation in vivo, biochemistry of mycobacteria


Sources

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46. Subramaniam R., Rao G., Pai S. P. N. 2D QSAR studies of some novel quinazolinone derivatives as antitubercular agents. J. Comput. Met. Mol. Design 2011; 1(3), 69–82.

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48. Khuni R. C., Khedkar V. M., Chawda R. S., Chauhan N. A., Parikh A. R., Coutinho E. C. Synhthesis, antitubercular evaluation and 3D-QSAR study of N- phenyl-3.(4-fluorphenyl)-4-substituted pyrazole derivatives. Bioorg. Med. Chem. Letters 2012; 22(1), 666–678.

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67. Chopra S., Matsuyoma K., Tran T., Malerich J. P., Wan B., Franzblau S. G., Lun S., Guo H., Maiga C. M., Bishai W. R., Madrid P. B. Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis. J. Antimicrob. Chemother. 2012; 67(2), 415 –421.

68. Jatana N., Jangid S., Khare G., Tyagi A. K., Latha N. Molecular modeling studies of fatty acyl-CoA synthetase (FadD 13) from Mycobacterium tuberculosis – a potential target for the development of antitubercular drugs. J. Mol. Model. 2011; 17(1), 301–313.

69. Chiaradia L. D., Martins P. G. A., Cordeiro M. N. S., Guido R. V. C., Ecco G., Andricopulo A. D., Yunes R. A., Vernal J., Nunes R. J., Terenzi H. Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and Ptp B) J. Med. Chem. 2012; 55(1), 390–402.

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