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Extruze tavenin


Authors: Jana Šalandová 1,2;  Miloslava Rabišková 1
Authors‘ workplace: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
Published in: Čes. slov. Farm., 2012; 61, 87-92
Category: Review Articles

Overview

Extruze tavenin, metoda původem z průmyslu plastů, se stává v současnosti velice zajímavou technologií také ve farmacii. Počet špatně rozpustných léčiv s nízkou biologickou dostupností stále stoupá. Většina organických léčiv vykazuje polymorfii. Spolu s využitím vhodných nosných a dalších farmaceutických pomocných látek představuje extruze tavenin zajímavou možnost, jak zvýšit rozpustnost špatně rozpustných léčiv nebo zabránit vzniku nežádoucích polymorfů a jak zlepšit biologickou dostupnost problematických léčiv. Extruzi tavenin lze využít také při formování lékových forem s řízeným uvolňováním léčiv, např. pelet nebo filmů. Je to relativně levná, účinná a reprodukovatelná technologie bez použití rozpouštědel, která je šetrná k léčivům. Článek je přehledem možné využitelnosti této moderní technologie ve farmacii.

Klíčová slova:
extruze tavenin, zařízení, farmaceutické pomocné látky, pelety, filmy


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Pharmacy Clinical pharmacology
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