Chitosan pellets produced by extrusion-spheronisation
Authors:
L. Janovská; G. Škrabáková; D. Vetchý; M. Rabišková
Authors‘ workplace:
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků
Published in:
Čes. slov. Farm., 2009; 58, 21-27
Category:
Original Articles
Overview
Chitosan, an intensively studied semisynthetic polymer, has many possible uses due to its special parameters. Chitosan is also presently useful as an excipient in pharmaceutical industry due to its binding, mucoadhesive, viscosity-increasing and film-coating properties which depend on its concentration. Pellets, spherical multiple dosage forms, make possible to solve a lot of problems with oral administration of drugs thanks to its unique properties. In our experiment, matrix pellets containing theophyllin were made by extrusion/spheronisation method. Microcrystalline cellulose and chitosan with 91% degree of deacetylation in concentrations of 25, 35, 45, 55, 65 and 70% were used as matrix-forming excipients. The influence of chitosan concentration on liberation of drug was observed in media with different pH values. The most prolonged theophyllin release (3 hours) was achieved in phosphate buffer of pH 6.8 and chitosan concentration of 25–35%.
Key words:
chitosan – pellets – sustained release – extrusion/spheronisation
Sources
1. Kolektiv autorů: Český lékopis 2002. Praha: Grada Publishing 2002; 460–462, 1934–1936.
2. Säkkinen, M.: Academic Dissertation, University of Helsinki 2003; 3–8.
3. www.unige.ch/sciences/pharm/fagal/of-these.htm., 10. 1. 2007
4. Illum, L.: Pharm. Res., 1998; 15(9), 1326–1331.
5. Kumar, M. N. V. R.: React. Funct. Polym., 2002; 46, 1–27.
6. Säkkinen, M., Seppälä, U., Henänen, P. et al.: Eur. J. Pharm. Biopharm., 2002; 54, 33–40.
7. Rinaudo, M.: Prog. Polym. Sci., 2006; 31, 603–632.
8. Sabnis, S., Block, L. H.: Int. J. Biol. Macromol., 2000; 27, 181–186.
9. Bajerová, M., Gajdziok, J., Dvořáčková, K. et al.: Čes. slov. Farm., 2008; 57, 63–69.
10. Kollár, P., Suchý, P., Muselík, J. et al.: Čes. slov. Farm., 2008; 57, 11–16.
11. Lowman, A. M., Peppas, N. A.: In: Encyclopedia of controlled drug delivery, Mathowitz E., Volume 1, 1999, s. 397–415.
12. Dodane, V., Vilivalam ,V. D.: Pharm. Sci. Tech. To., 1998; 4 (6), 246–253.
13. Masteiková, R., Chalupová, Z., Šklubalová, Z.: Medicina, 2003; 39 (Suppl. 2), 19–24.
14. Chandy, T., Sharma, Ch. P.: Biomaterials, 1993; 14 (12), 939–944.
15. Haznos, L., Langer, I., Gyamathy, M.: Drug Dev. Ind. Pharm., 1992; 18, 409–412.
16. Kolektiv autorů: Český lékopis 2005, Doplněk 2006. Praha: Grada Publishing 2006; 3361–3362.
17. Sienkiewicz, G., Pereira, R., Rudnic, E. M.: Drug Dev. Ind. Pharm., 1997; 23, 173–177.
18. Rabišková, M., Häring, A., Minczingerová, K. et al.: Chem. Listy, 2007; 101, 70–77.
19. Krejčová, K., Rabišková, M., Vetchý, D. et al.: Drug Dev. Ind. Pharm., 2006; 32, 585–593.
20. El Saleh, F., Kleinebudde, P.: Pharm. Tech. Europe, 1998; 10, 18–22.
21. Rodrigues, E. C., Torrado, J. J., Nikolakakis, I. et al.: Drug Dev. Ind. Pharm., 2001; 27, 847–855.
22. Sienkiewicz, G., Pereira, R., Rudnic, E. M. et al.: Drug Dev. Ind. Pharm., 1997; 23, 173–182.
23. Vertommen J., Kinget R.: Drug Dev. Ind. Pharm., 1997; 23, 39–46.
24. Robinson, J. R., Lee, V. H.: In: Controlled Drug Delivery. New York and Basel: Marcel Dekker 1987; 388–396.
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2009 Issue 1
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