The effect of lipophilic carrier concentration on hydrophilic-lipophilic matrix systems characteristics
Authors:
K. Dvořáčková; M. Rabišková; R. Masteiková; L. Okáčová
Authors‘ workplace:
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků
Published in:
Čes. slov. Farm., 2008; 57, 269-274
Category:
Original Articles
Overview
The present experimental paper aimed to examine the effect of lipophilic carrier concentration on diclofenac sodium prolonged release from hydrophilic-lipophilic matrix tablets with respect to the optimization of its dissolution profile in vitro. The lipophilic carrier was cetyl alcohol contemporaneously acting as the melting binder in thermoplastic granulation, povidone was used as the gel-forming agent, sucrose or lactose were fillers. The obtained results indicated that cetyl alcohol concentration influenced both characteristics of the granulates and the tablets. The dissolution profile of sucrose samples was affected statistically significantly by cetyl alcohol concentration, in the case of lactose samples only when a higher cetyl alcohol concentration was used. The increasing concentration of cetyl alcohol led to a slower drug release. From the obtained results it is apparent that sucrose samples released drug faster in comparison with the lactose monohydrate ones, especially when a lower lipid carrier concentration was used.
Key words:
matrix tablets – controlled release – cetyl alcohol – melt granulation
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Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2008 Issue 6
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