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Pellets preparation by the drug layering technique in a rotary processor


Authors: M. Švarcová;  D. Vetchý
Authors‘ workplace: Farmaceutická fakulta, Veterinární a Farmaceutická Univerzita Brno, Ústav technologie léků
Published in: Čes. slov. Farm., 2007; 56, 67-72
Category: Review Articles

Overview

Pelletization by the layering technique can be carried out by applying a liquid (a drug solution or suspension) or a drug powder using either coating drums or a fluidized bed equipment. This technique is used particularly for the formulation of multiparticulate controlled release dosage forms. Application of a drug on inactive beads in a centrifugal fluid-bed equipment (a rotary processor) represents the up-to-date technique of pellets production. Pelletization by the tangential drug-layering process is a multivariate process, and it is important to identify as well as to control the process variables and conditions. The goal of this paper is to give a summary about one of the newest pelletizing technologies – drug layering in a rotary processor, to outline its possibilities, and particularly to describe the influence of formulation and process parameters on the properties of the final product.

Key words:
pellets – powder layering – suspension and solution layering – rotoprocessor


Labels
Pharmacy Clinical pharmacology
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