A Study of Physicochemical Properties of 2-, 3-, 4-Alkoxyphenylcarbamic Acid Derivatives with a Substituted N-Phenylpiperazine Moiety in the Basic Part
Authors:
I. Malík; E. Sedlárová; J. Čižmárik; F. Andriamainty; J. Csöllei 1
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej chémie, SR
; Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav chemických léčiv
1
Published in:
Čes. slov. Farm., 2005; 54, 235-239
Category:
Original Articles
Overview
The paper presents the study of some physicochemical properties of 2-, 3-, 4-alkoxy- phenylcarbamic acid derivatives with various substituted N-phenylpiperazin-1-yl moiety in the basic part of the molecule. Elemental analysis, melting point, solubility, surface activity, dissociation constant and some lipophilicity parameters i.e. – partition coefficient, capacity factor obtained from HPLC, and RM values from reversed-phase thin-layer chromatography were determined.
Key words:
substituted N-phenylpiperazine moiety – physicochemical properties – phenylcarbamates
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 5
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