Analytical Evaluation of 1-(Dipropalamino-3-piperidine-propane-1-yl)-3-pentyloxyphenylcarbamate(CK-3635)

Czech version

Authors: I. Malík; E. Sedlárová; J. Csöllei ¹
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava 1Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno
Published in: Čes. slov. Farm., 2004; , 256-260
Category:

Overview

The paper presents the results of analytical and pharmacological evaluation and study of somephysicochemical properties of a potential drug marked as CK-3635 with high local anaestheticactivity. The structure of the substance has been confirmed by IR and UV spectroscopy. The meltingpoint, solubility, partition coefficient, capacity factor, surface activity, and dissociation constant weredetermined. The chromatographic behaviour of the drug on a thin layer was also investigated. Forthe content determination, spectrophotometry in the ultraviolet region of the spectrum at thewavelenght of the second absorption maximum of the substance, the titration in the two-phasesambient, and high-performance liquid chromatography were used.

Key words:
CK-3635 – analytical evaluation – physicochemical properties –content determination

Full text is not available online.

If interested in a scan of this journal, contact NTO ČLS JEP.