Authors: K. Kuča; J. Cabal Authors‘ workplace: Katedra toxikologie Vojenské lékařské akademie Jana Evangelisty Purkyně, Hradec Králové Published in: Čes. slov. Farm., 2004; , 93-95 Category:
The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2--oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerveagent sarin [O-isopropylmethylfluorophosphonate] was evaluated. The reactivators 2-PAM [2-hydroxyiminomethyl-1-methylpyridinium chloride], toxogonin [1,3-bis(4-hydroxyiminomethylpyridinium)-2-oxa-propane dichloride] and H-oxime HI-6 [1-(2-hydroxyiminomethylpyridinium)--3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] were chosen for comparison. The oxime HS-6was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, butit is better than 2-PAM and obidoxime.
Key words: acetylcholinesterase – sarin – HS-6 – HI-6 – obidoxime – 2-PAM – in vitro
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