Effect of Auxiliary Substances on the Physicochemical Indices of the Solutionsof Substance XXII B*

Czech version

Authors: Z. Vitková; K. Gardavská; M. Šubová; E. Cirbusová; M. Mišeková
Authors‘ workplace: Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2004; , 96-98
Category:

Overview

Within a study of optimization of auxiliary substances in the formulation of a hydrogel containinga potential local anaesthetic agent, substance XXII B, the paper evaluated the effect of a preservative(Ajatin) and humectants (glycerol, propylene glycol, sorbitol) on selected physicochemicalindices, which included the partition coefficient, surface tension, and viscosity of the solutions ofpotential drug XXII B. On the basis of the statistical evaluation of the results, the optimalcombination of auxiliary substances in this case seems to be Ajatin + glycerol.

Key words:
potential drugs XXII B – humectants – preservatives – physiochemical indices

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