Hydrophilic Gel Matrix Tablets for Oral Administration of Drugs

Overview

Matrix tablets with a dispersed active ingredient are the simplest concept in the design of dosageforms with modified drug release. If they contain a swelling polymer as an auxiliary substance, therelease from these systems, after initial liberation of a portion of the active ingredient from thesurface, takes place by diffusion, erosion, or a combination of both mechanisms in dependence onthe solubility of the contained active ingredient. Although hydrophilic matrix tablets have becomea well-tried and widely used dosage form with retarded effects, their research continues and newauxiliary substances and their combinations are being tested. The present paper reviews theknowledge published in this field in recent years.

Key words:
matrix tablets – hydrophilic polymers – modified drug release