HPLC Analysis of Non-Steroidal Antirheumatics in Biological MaterialV. Fenamates
Authors:
J. Sochor; J. Klimeš; J. Sedláček; M. Hnilová
Authors‘ workplace:
Katedra farmaceutické chemie a kontroly léčiv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové, Katedra patologické fyziologie Lékařské fakulty Univerzity Karlovy, Hradec Králové
Published in:
Čes. slov. Farm., 2001; , 303-307
Category:
Overview
The present paper surveys published HPLC methods estimating derivates of fenamic acid inbiological materials and an HPLC method for estimation of meclofenamic acid in the samples ofwhole blood. Meclofenamic acid was isolated from the sample of the blood both liquid-liqud extractionand solid-liquid extraction. For determination of meclofenamic acid in the blood was preferredsolid-liquid extraction. The adjust sample was analysed on reverse phase Separon SGX C-18 withthe mobile phase methanol – water (pH 2.3) and detected at 220 nm. The method was used ina pharmacokinetic study of meclofenamic acid on rabbits.
Key words:
HPLC – review of fenamic acid derivates – meclofenamic acid – blood samples –pharmacokinetics
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 6
Most read in this issue
- Monodesmosidic Saponins from Cynara cardunculus L.
- A Study of the Anticomplementary Activity of Mahonia aquifolium Crude Extract,Bisbenzylisoquinoline Alkaloids, and Berberine
- Advances in the Development of New Antituberculotics from the Group of Ortho-Condensed Heterocyclic CompoundsPart 3. Compounds Containing More Sorts of Heteroatoms in the Six-Membered Ring
- Experiments with the Cultivation of Hypericum perforatum L. in Bratislava