Density of Lyophilised Ophthalmic Lamellae3. Effects on the Density Due to Addition of Pilocarpinium Chloride or ScopolaminiumBromide

Overview

The paper examines the effects on the density of ophthalmic lamellae obtained by lyophilisation ofthe hydrogel of hydroxypropylmethylcellulose (HPMC 4000) in a concentration of 40 g/l due to anaddition of pilocarpinium chloride or scopolaminium bromide. The density of the basic xerogel66.4 g/l is markedly increased in the presence of 54.3 g/l pilocarpinium chloride. On the other hand,a lower concentration of 11.4 g/l scopolaminium bromide slightly decreases the density. Changes indensity influence the actual concentration of the active ingredient in hydrated lamellae. Changesare marked primarily in pilocarpinium chloride where changes in the density of lyophilisedophthalmic lamellae must be paid special attention to.

Key words:
density – lyophilisation – hydroxypropylmethylcellulose – pilocarpinium chloride –scopolaminium bromide