Authors: B. Friedecký Published in: Klin. Biochem. Metab., 33, 2025, No. 4, p. 154-155 doi: https://doi.org/10.61568/kbm.2025.015
In 2025, several comprehensive educational communications were published on the practical aspects of lipid-related international recommendations, intended for application in the routine activities of clinical laboratories. The first comes from ADLM - Association of Diagnostics and Laboratory Medicine, the second communication is from HEART UK and ALM (Association of Laboratory Medicine) UK. Both publications emphasize unresolved analytical issues in LDL-C determination methods, particularly the interference caused by elevated triglyceride concentrations and the resulting accuracy of diagnostic decision limits for dyslipidemia. Both works explicitly favor the calculation of LDL-C over its direct measurement, especially in American and British recommendations. This is contrary to common practice in our country and in Europe and therefore deserves increased attention.
dyslipidemia – LDL-C – guidelines ESC/EAT
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