Authors: I. Procházka Authors‘ workplace: Lékarna Plus, Praha Published in: Čes. slov. Farm., 2002; , 99-101 Category:
Within pre-formulation studies of phenylcarbamic acid derivatives with local anaesthetic effects, potential drog IV with the chemical name N-(2-(2-ethylphenylcarbamoyloxy)-ethyl)-piperidiniumchloride was examined. The study evaluated the effect of polyhydric alcohols - glycerol, propylene glycol, sorbitol and their concentrations of 5; 10; 15, and 20 wt % on the values of the partition coefficient in the system n-octanoUwater, surface tension, and viskozity of the solutions of potential drog IV. The optimal auxiliary substance seems to be glycerol of a concentration of 15-20 wt %, as it does not affect the values of the partition coefficient and surface tension of potential drog IV solutions in a statistically significant manner.
Key words: partition coefficient - surface tension - viskozity - N-(2-(2-ethylphenylcarbamoyloxy)-ethyl)-piperidiniumchloride
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