Lipid variability
Authors:
Dukát A. 1; Kriška M. 2; Payer J. 1
Authors‘ workplace:
V. interná klinika LF UK a UN Bratislava
1; Ústav farmakológie a klinickej farmakológie LF UK, Bratislava
2
Published in:
Kardiol Rev Int Med 2019, 21(2): 70-72
Overview
All biological systems share the common characteristic of having biological rhythms and variability. This variability is determined by several factors, which can be categorised as intrinsic and extrinsic factors. Genetic and environmental factors interact with and influence one another. This results in the variability of expressions and actions of the living organism as a whole. This overview discusses those facts that are of importance in terms of the prognosis and for determining a patient’s global cardiovascular risk.
Keywords:
Atherosclerosis – dyslipidaemia – variability
Sources
1. Yusuf S, Cairins JA, Camm AJ et al. (eds) Evidence based cardiology. 3rd ed. London: BMJ Books 2003.
2. Kelly GS. Seasonal variations of selected cardiovascular risk factors. Altem Med Rev 2005; 10(4): 307–320.
3. Deeg M. Lipid topics. Variations in lipid values. Clin Chem 1990: 1(3): 1–4. Available at: http:/ / www.testsymptomsathome.com/ pol01_arc_cardiochek-variations-in-lipid-values.pdf.
4. Myers GL, Cooper GR, Winn CL et al. The Centers for Disease Control National Heart, Lung and Blood Institute Lipid Standardization Program. An ap-proach to accurate and precise lipid measurements. Clin Lab Med 1989; 9(1): 105–135.
5. Pereira MA, Weggemans RM, Jacobs DR et al. Within-person variation in serum lipids: implications for clinical trials. Int J Epidemiol 2004; 33(3): 534–541. doi: 10.1093/ ije/ dyh057.
6. Mann DM, Glazer NL, Winter M et al. A pilot study identifying statin non-adherence with visit-to-visit variability of low density lipoprotein-choleste-rol. Am J Cardiol 2013; 111(10): 1437–1442. doi: 10.1016/ j.amjcard.2013.01.297.
7. Boey E, Gay GM, Poh KK et al. Visit-to-visit variability in LDL- and HDL-cholesterol is associated with adverse events after ST-segment elevation myocardial infarction: A 5-year follow-up study. Atherosclerosis 2016; 244: 86–92. doi: 10.1016/ j.atherosclerosis.2015.10.110.
8. Sathyapalan T, Atkin SL, Kilpatrick ES et al. Low density lipoprotein-choles-terol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: justification for direct measurement? Diab Obes Metabol 2010; 12(6): 540–544. doi: 10.1111/ j.1463-1326.2009.01190.x.
9. Sathyapalan T, Atkin SL, Kilpatrick ES. Variability of lipids in patients with type 2 diabetes taking statin treatment: implications for target setting. Diab Med 2008; 25(8): 909–915. doi: 10.1111/ j.1464-5491.2008.02519.x.
10. Bangalore S. Visit-to-visit low density lipoprotein-cholesterol variability and risk of cardiovascular outcomes: insights from the treating to new tar-gets trial. ESC lecture 2012. Available at: www.escardio.org.
11. Toth PP, Bays H, Farnier M et al. Variability of LDL-C lowering responses to statin and eze+statin therapy in achievement of ACC/ AHA Target Levels. AHA 2015. Available at: www.lipid.org.
12. Baber U, Halperin JL. Variability in low-density lipoprotein cholesterol and cardiovascular risk. Should consistency be a new target? J Amer Coll Cardiol 2015; 65(15): 1549–1551. doi: 10.1016/ j.jacc.2015.02.048.
13. Lefevre M, Champagne CM, Tulley RT et al. Individual variability in car-diovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol. Am J Clin Nutr 2005; 82(5): 957–963.
14. Tsalamandris C, Panagiotopoulos S, Allen TJ et al. Long-term intraindivi-dual variability of serum lipids in patients with type I and type II diabetes. J Diabetes Complications 1998; 12(4): 208–214.
15. Yildirimkaya M, Bil GC, Ozata M et al. Biological variation of serum lipids and lipoproteins in patients with clinically well controlled non insulin dependent diabetes mellitus. Endocr J 1996; 43(3): 345–351.
16. Smit RA, Trompet S, Sabayan B et al. Higher visit-to visit low-density lipoprotein cholesterol variability is associated with lower cognitive perfor-mance, lower cerebral blood flow, and grater white matter hyperintensity load in older subjects. Circulation 2016; 134(3): 212–221. doi: 10.1161/ CIRCULATIONAHA.115.020627.
17. Yang N, Feng JP, Chen G et al. Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris. Eur Rev Med Pharmacol Sci 2014; 18(24): 3761–3766.
18. Karlson BW, Wiklund O, Palmer MK et al. Variability of low-density lipo-protein cholesterol response with different doses of atorvastatin, rosuvastatin, and simvastatin: results from VOYAGER. Eur Heart J Cardiovasc Pharmacother 2016; 2(4): 212–217. doi: 10.1093/ ehjcvp/ pvw006.
19. Pereira MA, Weggemans RM, Jacobs DR et al. Within-person variation in serum lipids: implications for clinical trials. Int J Epidemiol 2004; 33(3): 534–541. doi: 10.1093/ ije/ dyh057.
20. Sabatine MS, Giugliano RP, Wiviott SD et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015; 372: 1500–1509. doi: 10.1056/ NEJMoa1500858.
21. Pallaud C, Gueguen R, Sass C et al. Genetic influences on lipid metabolism trait variability within the Stanislas Cohort. J Lipid Res 2001; 42(11): 1879–1890.
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Paediatric cardiology Internal medicine Cardiac surgery CardiologyArticle was published in
Cardiology Review
2019 Issue 2
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