Adherence to therapy in arterial hypertension
Authors:
Čapek B. 1; Václavík J. 2
Authors‘ workplace:
Interní oddělení, Sdružené zdravotnické zařízení Krnov, p. o.
1; I. interní klinika – kardiologická LF UP a FN Olomouc
2
Published in:
Kardiol Rev Int Med 2019, 21(1): 45-48
Overview
Poor adherence to medication therapy is the main cause of seemingly treatment-resistant hypertension. There are many different factors either positively or negatively contributing to non-adherence. Good adherence is associated with better quality of life, it reduces cardiovascular risk, incidence of stroke (uncontrolled hypertension is the main reason for ischaemic as well as haemorrhagic stroke) and number of hospital readmissions. The screening for non-adherence consists of self-reported questionnaires, pill counting, electronic monitoring systems and direct drug monitoring in blood or urine. Every single intervention and mainly their combination has great benefits for adherence, but also for the clinical outcome and patient prognosis. Inclusion of screening and subsequent intervention should therefore become a common part of everyday clinical practice.
Keywords:
resistant hypertension – adherence – cardiovascular outcome
Sources
1. Malta DC, Gonçalves RP, Machado ÍE et al. Prevalence of arterial hypertension according to different diagnostic criteria, National Health Survey. Rev Bras Epidemiol 2018; 21 (Suppl 1): e180021. doi: 10.1590/ 1980-549720180021.supl.1
2. Noubiap JJ, Nansseu JR, Nyaga UF et al. Global prevalence of resistant hypertension: a meta-analysis of data from 3.2 million patients. Heart 2019; 105(2): 98– 105. doi: 10.1136/ heartjnl-2018-313599.
3. Ruzicka M, Hiremath S. Can drugs work in patients who do not take them? The problem of non-adherence in resistant hypertension. Curr Hypertens Rep 2015; 17(9): 579. doi: 10.1007/ s11906-015-0579-4.
4. Abegaz TM, Shehab A, Gebreyohannes EA et al. Nonadherence to antihypertensive drugs. Medicine (Baltimore) 2017; 96(4): e5641. doi: 10.1097/ MD.0000000000005641.
5. de Jager RL, van Maarseveen EM, Bots ML et al. Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial. Br J Clin Pharmacol 2018; 84(1): 18– 24. doi: 10.1111/ bcp.13402.
6. Ghimire S, Castelino RL, Lioufas NM et al. Nonadherence to medication therapy in haemodialysis patients: a systematic review. PLoS One 2015; 10(12): e0144119. doi: 10.1371/ journal.pone.0144119.
7. Roldan PC, Ho GY, Ho PM. Updates to adherence to hypertension medications. Curr Hypertens Rep 2018; 20(4): 34. doi: 10.1007/ s11906-018-0830-x.
8. Najimi A, Mostafavi F, Sharifirad G et al. Barriers to medication adherence in patients with hypertension: a qualitative study. J Educ Health Promot 2018; 7: 24. doi: 10.4103/ jehp.jehp_65_16.
9. Ashoorkhani M, Majdzadeh R, Gholami J et al. Understanding non-adherence to treatment in hypertension: a qualitative study. Int J community Based Nurs Midwifery 2018; 6(4): 314– 323.
10. Chudiak A, Uchmanowicz I, Mazur G. Relation between cognitive impairment and treatment adherence in elderly hypertensive patients. Clin Interv Aging 2018; 13: 1409– 1418. doi: 10.2147/ CIA.S162701.
11. Choi HY, Oh IJ, Lee JA et al. Factors affecting adherence to antihypertensive medication. Korean J Fam Med 2018; 39(6): 325– 332. doi: 10.4082/ kjfm.17.0041.
12. Al-Noumani H, Wu JR, Barksdale D et al. Health beliefs and medication adherence in omanis with hypertension. J Cardiovasc Nurs 2018; 33(6): 518– 526. doi: 10.1097/ JCN.0000000000000511.
13. Mzoughi K, Zairi I, Jemai A et al. Factors associated with poor medication compliance in hypertensive patients. Tunis Med 2018; 96(6): 385– 390.
14. Vicente-Sánchez S, Olmos-Jiménez R, Ramírez-Roig C et al. Treatment adherence in patients older than 65 years who suffer early readmissions. Farm Hosp 2018; 42(4): 147– 151. doi: 10.7399/ fh.10907.
15. Chen MJ, Wu CC, Wan LH et al. Association between medication adherence and admission blood pressure among patients with ischemic stroke. J Cardiovasc Nurs 2019; 34(2): E1– E8. doi: 10.1097/ JCN.0000000000000541.
16. Assawasuwannakit P, Braund R, Duffull SB. A model-based meta-analysis of the influence of factors that impact adherence to medications. J Clin Pharm Ther 2015; 40(1): 24– 31. doi: 10.1111/ jcpt.12219.
17. Krousel-Wood M, Joyce C, Holt E et al. Predictors of decline in medication adherence. Hypertension 2011; 58(5): 804– 810. doi: 10.1161/ HYPERTENSIONAHA.111.176859.
18. Souza AC de, Borges JW, Moreira TM. Quality of life and treatment adherence in hypertensive patients: systematic review with meta-analysis. Rev Saude Publica 2016; 50: 71. doi: 10.1590/ S1518-8787.2016050006415.
19. Khayyat SM, Mohamed MM, Khayyat SM et al. Association between medication adherence and quality of life of patients with diabetes and hypertension attending primary care clinics: a cross-sectional survey. Qual Life Res 2018. doi: 10.1007/ s11136-018-2060-8.
20. Park NH, Song MS, Shin SY et al. The effects of medication adherence and health literacy on health-related quality of life in older people with hypertension. Int J Older People Nurs 2018; 13(3): e12196. doi: 10.1111/ opn.12196.
21. Corrao G, Parodi A, Nicotra F et al. Better compliance to antihypertensive medications reduces cardiovascular risk. J Hypertens 2011; 29(3): 610– 618. doi: 10.1097/ HJH.0b013e328342ca97.
22. Xu T, Yu X, Ou S et al. Adherence to antihypertensive medications and stroke risk: a dose-response meta-analysis. J Am Heart Assoc 2017; 6(7): pii: e006371. doi: 10.1161/ JAHA.117.006371.
23. Overgaauw N, Alsma J, Brink A et al. Drug nonadherence is a common but often overlooked cause of hypertensive urgency and emergency at the emergency department. J Hypertens 2019. [Epub ahead of print] doi: 10.1097/ HJH.0000000000002005.
24. Durand H, Hayes P, Morrissey EC et al. Medication adherence among patients with apparent treatment-resistant hypertension: systematic review and meta-analysis. J Hypertens 2017; 35(12): 2346– 2357. doi: 10.1097/ HJH.0000000000001502.
25. Forbes CA, Deshpande S, Sorio-Vilela F et al. A systematic literature review comparing methods for the measurement of patient persistence and adherence. Curr Med Res Opin 2018; 34(9): 1613– 1625. doi: 10.1080/ 03007995.2018.1477747.
26. Avataneo V, De Nicolò A, Rabbia F et al. Therapeutic drug monitoring-guided definition of adherence profiles in resistant hypertension and identification of predictors of poor adherence. Br J Clin Pharmacol 2018; 84(11): 2535– 2543. doi: 10.1111/ bcp.13706.
27. Meddings J, Kerr EA, Heisler M et al. Physician assessments of medication adherence and decisions to intensify medications for patients with uncontrolled blood pressure: still no better than a coin toss. BMC Health Serv Res 2012; 12: 270. doi: 10.1186/ 1472-6963-12-270.
28. Belknap R, Weis S, Brookens A et al. Feasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapy. PLoS One 2013; 8(1): e53373. doi: 10.1371/ journal.pone.0053373.
29. Matthes J, Albus C. Improving adherence with medication: a selective literature review based on the example of hypertension treatment. Dtsch Arztebl Int 2014; 111(4): 41– 47. doi: 10.3238/ arztebl.2014.0041.
30. Xu R, Xie X, Li S et al. Interventions to improve medication adherence among Chinese patients with hypertension: a systematic review and meta-analysis of randomized controlled trails. Int J Pharm Pract 2018; 26(4): 291– 301. doi: 10.1111/ ijpp.12452.
31. Conn VS, Ruppar TM, Chase JA et al. Interventions to improve medication adherence in hypertensive patients: systematic review and meta-analysis. Curr Hypertens Rep 2015; 17(12): 94. doi: 10.1007/ s11906-015-0606-5.
32. Roter DL, Hall JA, Merisca R et al. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care 1998; 36(8): 1138– 1161.
33. Fletcher BR, Hartmann-Boyce J, Hinton L et al. The effect of self-monitoring of blood pressure on medication adherence and lifestyle factors: a systematic review and meta-analysis. Am J Hypertens 2015; 28(10): 1209– 1221. doi: 10.1093/ ajh/ hpv008.
34. McManus RJ, Mant J, Bray EP et al. Telemonitoring and self-management in the control of hypertension (TASMINH2): a randomised controlled trial. Lancet 2010; 376(9736): 163– 172. doi: 10.1016/ S0140-6736(10)60964-6.
35. Gwadry-Sridhar FH, Manias E, Lal L et al. Impact of interventions on medication adherence and blood pressure control in patients with essential hypertension: a systematic review by the ISPOR medication adherence and persistence special interest group. Value Health 2013; 16(5): 863– 871. doi: 10.1016/ j.jval.2013.03.1631.
36. Magrin ME, D’Addario M, Greco A et al. Social support and adherence to treatment in hypertensive patients: a meta-analysis. Ann Behav Med 2015; 49(3): 307– 318. doi: 10.1007/ s12160-014-9663-2.
37. Williams B, Mancia G, Spiering W et al. 2018 ESC/ ESH Guidelines for the management of arterial hypertension. Euro Heart J 2018; 39(33): 3021– 3104. doi: 10.1093/ eurheartj/ ehy339.
38. Corrao G, Parodi A, Zambon A et al. Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J Hypertens 2010; 28(7): 1584– 1590. doi: 10.1097/ HJH.0b013e328339f9fa.
39. Lauffenburger JC, Landon JE, Fischer MA. Effect of combination therapy on adherence among us patients initiating therapy for hypertension: a cohort study. J Gen Intern Med 2017; 32(6): 619– 625. doi: 10.1007/ s11606-016-3972-z.
40. Bangalore S, Kamalakkannan G, Parkar S et al. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007; 120(8): 713– 719. doi: 10.1016/ j.amjmed.2006.08.033.
41. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55(2): 399– 407. doi: 10.1161/ HYPERTENSIONAHA.109.139816.
42. Kumagai N, Onishi K, Hoshino K et al. Improving drug adherence using fixed combinations caused beneficial treatment outcomes and decreased health-care costs in patients with hypertension. Clin Exp Hypertens 2013; 35(5): 355– 360. doi: 10.3109/ 10641963.2012.732644.
43. Verma AA, Khuu W, Tadrous M et al. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study. PLoS Med 2018; 15(6): e1002584. doi: 10.1371/ journal.pmed.1002584.
44. Márquez Contreras E, Márquez Rivero S, Rodríguez García E et al. Specific hypertension smartphone app to improve medication adherence in hypertension: a cluster-randomized trial. Curr Med Res Opin 2018; 35(1): 1– 15. doi: 10.1080/ 03007995.2018.1549026.
45. Morawski K, Ghazinouri R, Krumme A et al. Association of a smartphone application with medication adherence and blood pressure control: The MedISAFE-BP randomized clinical trial. JAMA Intern Med 2018; 178(6): 802– 809. doi: 10.1001/ jamainternmed.2018.0447.
46. Sherrill B, Halpern M, Khan S et al. Single-pill vs free-equivalent combination therapies for hypertension: a meta-analysis of health care costs and adherence. J Clin Hypertens (Greenwich) 2011; 13(12): 898– 909. doi: 10.1111/ j.1751-7176.2011.00550.x.
Labels
Paediatric cardiology Internal medicine Cardiac surgery CardiologyArticle was published in
Cardiology Review
2019 Issue 1
Most read in this issue
- Comparison of the benefits of FGM and CGM for different clinical scenarios in patients with type 1 diabetes mellitus
- The role of nebivolol in the treatment of cardiovascular diseases
- The most common causes of hospitalisation and death in patients with diabetes – results of the National Diabetology Registry
- Screening of asymptomatic carotid atherosclerosis in diabetic patients and its association with ankle-brachial index